TY - JOUR
T1 - Targeted delivery of magnetic aerosol droplets to the lung
AU - Dames, Petra
AU - Gleich, Bernhard
AU - Flemmer, Andreas
AU - Hajek, Kerstin
AU - Seidl, Nicole
AU - Wiekhorst, Frank
AU - Eberbeck, Dietmar
AU - Bittmann, Iris
AU - Bergemann, Christian
AU - Weyh, Thomas
AU - Trahms, Lutz
AU - Rosenecker, Joseph
AU - Rudolph, Carsten
PY - 2007/8
Y1 - 2007/8
N2 - The inhalation of medical aerosols is widely used for the treatment of lung disorders such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, respiratory infection and, more recently, lung cancer. Targeted aerosol delivery to the affected lung tissue may improve therapeutic efficiency and minimize unwanted side effects. Despite enormous progress in optimizing aerosol delivery to the lung, targeted aerosol delivery to specific lung regions other than the airways or the lung periphery has not been adequately achieved to date. Here, we show theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles - so-called nanomagnetosols - in combination with a target-directed magnetic gradient field. We suggest that nanomagnetosols may be useful for treating localized lung disease, by targeting foci of bacterial infection or tumour nodules.
AB - The inhalation of medical aerosols is widely used for the treatment of lung disorders such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, respiratory infection and, more recently, lung cancer. Targeted aerosol delivery to the affected lung tissue may improve therapeutic efficiency and minimize unwanted side effects. Despite enormous progress in optimizing aerosol delivery to the lung, targeted aerosol delivery to specific lung regions other than the airways or the lung periphery has not been adequately achieved to date. Here, we show theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles - so-called nanomagnetosols - in combination with a target-directed magnetic gradient field. We suggest that nanomagnetosols may be useful for treating localized lung disease, by targeting foci of bacterial infection or tumour nodules.
UR - http://www.scopus.com/inward/record.url?scp=34547672749&partnerID=8YFLogxK
U2 - 10.1038/nnano.2007.217
DO - 10.1038/nnano.2007.217
M3 - Article
C2 - 18654347
AN - SCOPUS:34547672749
SN - 1748-3387
VL - 2
SP - 495
EP - 499
JO - Nature Nanotechnology
JF - Nature Nanotechnology
IS - 8
ER -