Taming the young and restless - Epigenetic gene regulation in pancreas and beta-cell precursors

Holger A. Russ; Matthias Hebrok

doi:10.15252/embj.201489751

Taming the young and restless - Epigenetic gene regulation in pancreas and beta-cell precursors

Holger A. Russ, Matthias Hebrok

University of California San Francisco

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

The in vivo assessment of epigenetic changes during mouse pancreatic beta-cell differentiation reveals surprising differences to directed, in vitro differentiation of human embryonic stem cells. New findings reported in this issue of The EMBO Journal further identify Ezh2 as a critical determinant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapies.

Original language	English
Pages (from-to)	2135-2136
Number of pages	2
Journal	EMBO Journal
Volume	33
Issue number	19
DOIs	https://doi.org/10.15252/embj.201489751
State	Published - 2014
Externally published	Yes

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title = "Taming the young and restless - Epigenetic gene regulation in pancreas and beta-cell precursors",

abstract = "The in vivo assessment of epigenetic changes during mouse pancreatic beta-cell differentiation reveals surprising differences to directed, in vitro differentiation of human embryonic stem cells. New findings reported in this issue of The EMBO Journal further identify Ezh2 as a critical determinant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapies.",

author = "Russ, {Holger A.} and Matthias Hebrok",

note = "Publisher Copyright: {\textcopyright} 2014 The Authors.",

year = "2014",

doi = "10.15252/embj.201489751",

language = "English",

volume = "33",

pages = "2135--2136",

journal = "EMBO Journal",

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TY - JOUR

T1 - Taming the young and restless - Epigenetic gene regulation in pancreas and beta-cell precursors

AU - Russ, Holger A.

AU - Hebrok, Matthias

PY - 2014

Y1 - 2014

N2 - The in vivo assessment of epigenetic changes during mouse pancreatic beta-cell differentiation reveals surprising differences to directed, in vitro differentiation of human embryonic stem cells. New findings reported in this issue of The EMBO Journal further identify Ezh2 as a critical determinant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapies.

AB - The in vivo assessment of epigenetic changes during mouse pancreatic beta-cell differentiation reveals surprising differences to directed, in vitro differentiation of human embryonic stem cells. New findings reported in this issue of The EMBO Journal further identify Ezh2 as a critical determinant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapies.

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U2 - 10.15252/embj.201489751

DO - 10.15252/embj.201489751

M3 - Short survey

C2 - 25154606

AN - SCOPUS:84908099387

SN - 0261-4189

VL - 33

SP - 2135

EP - 2136

JO - EMBO Journal

JF - EMBO Journal

IS - 19

ER -

Taming the young and restless - Epigenetic gene regulation in pancreas and beta-cell precursors

Abstract

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