Abstract
Platelet talin nucleates actin assembly as we show here directly by using rhodamine-phalloidin labelling of actin filaments, Nucleation by talin still occurs after reconstitution into liposomal bilayers. This is also demonstrated directly after protein-lipid double labelling and light microscopic imaging. Talin, thus, is the first actin binding protein for which anchoring and nucleation of artin filament growth at lipid interfaces have been visualized.
Original language | English |
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Pages (from-to) | 203-205 |
Number of pages | 3 |
Journal | FEBS Letters |
Volume | 314 |
Issue number | 2 |
DOIs | |
State | Published - 14 Dec 1992 |
Keywords
- Actin nucleation
- Lipid binding
- Platelet
- Talin