Tailored Correlation Spectroscopy for the Enhancement of Fingerprint Cross Peaks in Peptides and Proteins

J. Quant; T. Prasch; S. Ihringer; S. J. Glaser

doi:10.1006/jmrb.1995.1021

Tailored Correlation Spectroscopy for the Enhancement of Fingerprint Cross Peaks in Peptides and Proteins

J. Quant, T. Prasch, S. Ihringer, S. J. Glaser

Johann Wolfgang Goethe University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A new experimental mixing scheme for band-selective Hartmann-Hahn transfer between the H^N and H_α resonances of peptides and proteins is presented. This form of tailored correlation spectroscopy (TACSY) allows enhancement of the sensitivity of specific (H^N-H_α)-fingerprint signals compared to broadband TOCSY experiments. The design criteria as well as experimental applications of the multiple-pulse sequence CABBY-1 are presented.

Original language	English
Pages (from-to)	116-121
Number of pages	6
Journal	Journal of Magnetic Resonance - Series B
Volume	106
Issue number	2
DOIs	https://doi.org/10.1006/jmrb.1995.1021
State	Published - Feb 1995
Externally published	Yes

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10.1006/jmrb.1995.1021

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title = "Tailored Correlation Spectroscopy for the Enhancement of Fingerprint Cross Peaks in Peptides and Proteins",

abstract = "A new experimental mixing scheme for band-selective Hartmann-Hahn transfer between the HN and Hα resonances of peptides and proteins is presented. This form of tailored correlation spectroscopy (TACSY) allows enhancement of the sensitivity of specific (HN-Hα)-fingerprint signals compared to broadband TOCSY experiments. The design criteria as well as experimental applications of the multiple-pulse sequence CABBY-1 are presented.",

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year = "1995",

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AU - Prasch, T.

AU - Ihringer, S.

AU - Glaser, S. J.

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AB - A new experimental mixing scheme for band-selective Hartmann-Hahn transfer between the HN and Hα resonances of peptides and proteins is presented. This form of tailored correlation spectroscopy (TACSY) allows enhancement of the sensitivity of specific (HN-Hα)-fingerprint signals compared to broadband TOCSY experiments. The design criteria as well as experimental applications of the multiple-pulse sequence CABBY-1 are presented.

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Tailored Correlation Spectroscopy for the Enhancement of Fingerprint Cross Peaks in Peptides and Proteins

Abstract

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