T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual

Till Bunse, Nina Koerber, Hannah Wintersteller, Jochen Schneider, Alexander Graf, Aleksandar Radonic, Andrea Thuermer, Max von Kleist, Helmut Blum, Christoph D. Spinner, Tanja Bauer, Percy A. Knolle, Ulrike Protzer, Eva C. Schulte

Research output: Contribution to journalArticlepeer-review

Abstract

Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual’s immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.

Original languageEnglish
Article number1562
JournalMicroorganisms
Volume11
Issue number6
DOIs
StatePublished - Jun 2023
Externally publishedYes

Keywords

  • B-and T-cell immunity
  • SARS-CoV-2
  • immunocompromise
  • protracted infection
  • variants

Fingerprint

Dive into the research topics of 'T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual'. Together they form a unique fingerprint.

Cite this