T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual

Till Bunse; Nina Koerber; Hannah Wintersteller; Jochen Schneider; Alexander Graf; Aleksandar Radonic; Andrea Thuermer; Max von Kleist; Helmut Blum; Christoph D. Spinner; Tanja Bauer; Percy A. Knolle; Ulrike Protzer; Eva C. Schulte

doi:10.3390/microorganisms11061562

T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual

Till Bunse, Nina Koerber, Hannah Wintersteller, Jochen Schneider, Alexander Graf, Aleksandar Radonic, Andrea Thuermer, Max von Kleist, Helmut Blum, Christoph D. Spinner, Tanja Bauer, Percy A. Knolle, Ulrike Protzer, Eva C. Schulte

Research output: Contribution to journal › Article › peer-review

Abstract

Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual’s immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.

Original language	English
Article number	1562
Journal	Microorganisms
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/microorganisms11061562
State	Published - Jun 2023

Keywords

B-and T-cell immunity
SARS-CoV-2
immunocompromise
protracted infection
variants

Access to Document

10.3390/microorganisms11061562

Cite this

Bunse, T., Koerber, N., Wintersteller, H., Schneider, J., Graf, A., Radonic, A., Thuermer, A., von Kleist, M., Blum, H., Spinner, C. D., Bauer, T., Knolle, P. A., Protzer, U., & Schulte, E. C. (2023). T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual. Microorganisms, 11(6), Article 1562. https://doi.org/10.3390/microorganisms11061562

@article{5aba3393a7874517ab278031390f3b2e,

title = "T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual",

abstract = "Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual{\textquoteright}s immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.",

keywords = "B-and T-cell immunity, SARS-CoV-2, immunocompromise, protracted infection, variants",

author = "Till Bunse and Nina Koerber and Hannah Wintersteller and Jochen Schneider and Alexander Graf and Aleksandar Radonic and Andrea Thuermer and {von Kleist}, Max and Helmut Blum and Spinner, {Christoph D.} and Tanja Bauer and Knolle, {Percy A.} and Ulrike Protzer and Schulte, {Eva C.}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jun,

doi = "10.3390/microorganisms11061562",

language = "English",

volume = "11",

journal = "Microorganisms",

issn = "2076-2607",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

Bunse, T, Koerber, N, Wintersteller, H, Schneider, J, Graf, A, Radonic, A, Thuermer, A, von Kleist, M, Blum, H, Spinner, CD, Bauer, T, Knolle, PA , Protzer, U & Schulte, EC 2023, 'T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual', Microorganisms, vol. 11, no. 6, 1562. https://doi.org/10.3390/microorganisms11061562

TY - JOUR

T1 - T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual

AU - Bunse, Till

AU - Koerber, Nina

AU - Wintersteller, Hannah

AU - Schneider, Jochen

AU - Graf, Alexander

AU - Radonic, Aleksandar

AU - Thuermer, Andrea

AU - von Kleist, Max

AU - Blum, Helmut

AU - Spinner, Christoph D.

AU - Bauer, Tanja

AU - Knolle, Percy A.

AU - Protzer, Ulrike

AU - Schulte, Eva C.

PY - 2023/6

Y1 - 2023/6

N2 - Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual’s immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.

AB - Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual’s immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.

KW - B-and T-cell immunity

KW - SARS-CoV-2

KW - immunocompromise

KW - protracted infection

KW - variants

UR - http://www.scopus.com/inward/record.url?scp=85164105695&partnerID=8YFLogxK

U2 - 10.3390/microorganisms11061562

DO - 10.3390/microorganisms11061562

M3 - Article

AN - SCOPUS:85164105695

SN - 2076-2607

VL - 11

JO - Microorganisms

JF - Microorganisms

IS - 6

M1 - 1562

ER -

T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this