Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs

Tilman Ziegler; Andrea Bähr; Andrea Howe; Katharina Klett; Wira Husada; Christian Weber; Karl Ludwig Laugwitz; Christian Kupatt; Rabea Hinkel

doi:10.1016/j.ymthe.2018.06.004

Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs

Tilman Ziegler
, Andrea Bähr
, Andrea Howe
, Katharina Klett
, Wira Husada
, Christian Weber
, Karl Ludwig Laugwitz
, Christian Kupatt
, Rabea Hinkel

Department of Internal Medicine I - Cardiology

Technical University of Munich
Partner Site Munich Heart Alliance
Ludwig-Maximilians-Universität München

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Cardiovascular risk factors, such as hypercholesterolemia, impair cardiac function in chronic ischemia. Ziegler et al. demonstrate that cardiac transduction of thymosin β4 is capable of inducing therapeutic neovascularization and, thereby, improving cardiac function in a translational large animal model with cardiovascular risk factor.

Original language	English
Pages (from-to)	1706-1714
Number of pages	9
Journal	Molecular Therapy
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.ymthe.2018.06.004
State	Published - 5 Jul 2018

Keywords

adeno-associated viral vectors
cardiovascular risk factors
gene therapy
hypercholesterolemia
myocardial ischemia
therapeutic neovascularization
thymosin β4

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10.1016/j.ymthe.2018.06.004

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@article{16f104d40e1c4fee9b6424088cb3a60e,

title = "Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs",

abstract = "Cardiovascular risk factors, such as hypercholesterolemia, impair cardiac function in chronic ischemia. Ziegler et al. demonstrate that cardiac transduction of thymosin β4 is capable of inducing therapeutic neovascularization and, thereby, improving cardiac function in a translational large animal model with cardiovascular risk factor.",

keywords = "adeno-associated viral vectors, cardiovascular risk factors, gene therapy, hypercholesterolemia, myocardial ischemia, therapeutic neovascularization, thymosin β4",

author = "Tilman Ziegler and Andrea B{\"a}hr and Andrea Howe and Katharina Klett and Wira Husada and Christian Weber and Laugwitz, \{Karl Ludwig\} and Christian Kupatt and Rabea Hinkel",

note = "Funding Information: We thank Tien Cuong Kieu, Elisabeth Raatz, and Anja Wolf for their excellent technical assistance. This work was supported by the German Ministry of Education and Research (BMBF, GENEVA, to C.K. and R.H.) and the Else-Kr{\"o}ner-Fresenius Stiftung (to C.K. and R.H.).",

year = "2018",

month = jul,

day = "5",

doi = "10.1016/j.ymthe.2018.06.004",

language = "English",

volume = "26",

pages = "1706--1714",

journal = "Molecular Therapy",

issn = "1525-0016",

publisher = "Cell Press",

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TY - JOUR

T1 - Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs

AU - Ziegler, Tilman

AU - Bähr, Andrea

AU - Howe, Andrea

AU - Klett, Katharina

AU - Husada, Wira

AU - Weber, Christian

AU - Laugwitz, Karl Ludwig

AU - Kupatt, Christian

AU - Hinkel, Rabea

N1 - Funding Information: We thank Tien Cuong Kieu, Elisabeth Raatz, and Anja Wolf for their excellent technical assistance. This work was supported by the German Ministry of Education and Research (BMBF, GENEVA, to C.K. and R.H.) and the Else-Kröner-Fresenius Stiftung (to C.K. and R.H.).

PY - 2018/7/5

Y1 - 2018/7/5

N2 - Cardiovascular risk factors, such as hypercholesterolemia, impair cardiac function in chronic ischemia. Ziegler et al. demonstrate that cardiac transduction of thymosin β4 is capable of inducing therapeutic neovascularization and, thereby, improving cardiac function in a translational large animal model with cardiovascular risk factor.

AB - Cardiovascular risk factors, such as hypercholesterolemia, impair cardiac function in chronic ischemia. Ziegler et al. demonstrate that cardiac transduction of thymosin β4 is capable of inducing therapeutic neovascularization and, thereby, improving cardiac function in a translational large animal model with cardiovascular risk factor.

KW - adeno-associated viral vectors

KW - cardiovascular risk factors

KW - gene therapy

KW - hypercholesterolemia

KW - myocardial ischemia

KW - therapeutic neovascularization

KW - thymosin β4

UR - https://www.scopus.com/pages/publications/85048824822

U2 - 10.1016/j.ymthe.2018.06.004

DO - 10.1016/j.ymthe.2018.06.004

M3 - Article

C2 - 29929787

AN - SCOPUS:85048824822

SN - 1525-0016

VL - 26

SP - 1706

EP - 1714

JO - Molecular Therapy

JF - Molecular Therapy

IS - 7

ER -

Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs

Abstract

Keywords

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