Systems-based analysis of modified tRNA bases

Daniel Globisch, David Pearson, Antje Hienzsch, Tobias Brückl, Mirko Wagner, Ines Thoma, Peter Thumbs, Veronika Reiter, Andrea Christa Kneuttinger, Markus Müller, Stephan A. Sieber, Thomas Carell

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Quantification of modified tRNA nucleosides in 16 species reveals evolutionary development of modification levels corresponding to phylogenetic branching. Comparison of modification profiles additionally allows characterization of species and differentiation between a number of pathogenic and harmless bacterial strains.

Original languageEnglish
Pages (from-to)9739-9742
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume50
Issue number41
DOIs
StatePublished - 4 Oct 2011
Externally publishedYes

Keywords

  • bioanalytical methods
  • isotopic labeling
  • molecular evolution
  • nucleosides
  • tRNA

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