Systematic study of the influence of base-step parameters on the electronic coupling between base-pair dimers: Comparison of A-DNA and B-DNA forms

Anela Ivanova, Philip Shushkov, Notker Rösch

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The electronic coupling is one of the key parameters governing electron hole transfer along DNA helices. In this study, we established the first comprehensive data base of electronic coupling elements, calculated at the ab initio level. The data set comprises all possible Watson-Crick base pair dimers, both in standard A-DNA and B-DNA geometries. We also quantified the sensitivity of the coupling elements with respect to geometry changes by varying each of the six standard base step parameters, which specify the relative orientation of neighboring base pairs. We compare the couplings in a systematic way by discussing variations in the coupling magnitude due to geometry or nucleotide sequence in the dimer, and we analyze how the structure affects the electronic coupling in terms of general and dimer-specific trends. Furthermore, we studied how the coupling changes when one introduces the chemically modified base 7-deazaguanine in the corresponding base-pair dimers. Finally, on the basis of the calculated coupling elements, we suggest a model duplex with an enhanced capacity for hole transfer.

Original languageEnglish
Pages (from-to)7106-7114
Number of pages9
JournalJournal of Physical Chemistry A
Volume112
Issue number30
DOIs
StatePublished - 31 Jul 2008

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