TY - JOUR
T1 - System-wide molecular evidence for phenotypic buffering in Arabidopsis
AU - Fu, Jingyuan
AU - Keurentjes, Joost J.B.
AU - Bouwmeester, Harro
AU - America, Twan
AU - Verstappen, Francel W.A.
AU - Ward, Jane L.
AU - Beale, Michael H.
AU - De Vos, Ric C.H.
AU - Dijkstra, Martijn
AU - Scheltema, Richard A.
AU - Johannes, Frank
AU - Koornneef, Maarten
AU - Vreugdenhil, Dick
AU - Breitling, Rainer
AU - Jansen, Ritsert C.
PY - 2009/2
Y1 - 2009/2
N2 - We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits. We found six QTL hot spots with major, system-wide effects, suggesting there are six breakpoints in a system otherwise buffered against many of the 500,000 SNPs.
AB - We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits. We found six QTL hot spots with major, system-wide effects, suggesting there are six breakpoints in a system otherwise buffered against many of the 500,000 SNPs.
UR - http://www.scopus.com/inward/record.url?scp=59149100506&partnerID=8YFLogxK
U2 - 10.1038/ng.308
DO - 10.1038/ng.308
M3 - Article
C2 - 19169256
AN - SCOPUS:59149100506
SN - 1061-4036
VL - 41
SP - 166
EP - 167
JO - Nature Genetics
JF - Nature Genetics
IS - 2
ER -