Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

Johannes Lehmann; Johannes Richers; Alexander Pöthig; Stephan A. Sieber

doi:10.1039/C6CC08365J

Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

Johannes Lehmann
, Johannes Richers
, Alexander Pöthig
, Stephan A. Sieber

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.

Original language	English
Pages (from-to)	107-110
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	1
DOIs	https://doi.org/10.1039/C6CC08365J
State	Published - 2017

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SDG 3 Good Health and Well-being

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10.1039/C6CC08365J

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title = "Synthesis of ramariolide natural products and discovery of their targets in mycobacteria",

abstract = "Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.",

author = "Johannes Lehmann and Johannes Richers and Alexander P{\"o}thig and Sieber, \{Stephan A.\}",

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year = "2017",

doi = "10.1039/C6CC08365J",

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journal = "Chemical Communications",

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T1 - Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

AU - Lehmann, Johannes

AU - Richers, Johannes

AU - Pöthig, Alexander

AU - Sieber, Stephan A.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.

AB - Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.

UR - https://www.scopus.com/pages/publications/85006867033

U2 - 10.1039/C6CC08365J

DO - 10.1039/C6CC08365J

M3 - Article

C2 - 27847948

AN - SCOPUS:85006867033

SN - 1359-7345

VL - 53

SP - 107

EP - 110

JO - Chemical Communications

JF - Chemical Communications

IS - 1

ER -

Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

Abstract

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