Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

Johannes Lehmann; Johannes Richers; Alexander Pöthig; Stephan A. Sieber

doi:10.1039/C6CC08365J

Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

Johannes Lehmann, Johannes Richers, Alexander Pöthig, Stephan A. Sieber

Chair of Organic Chemistry II

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.

Original language	English
Pages (from-to)	107-110
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	1
DOIs	https://doi.org/10.1039/C6CC08365J
State	Published - 2017

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abstract = "Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.",

author = "Johannes Lehmann and Johannes Richers and Alexander P{\"o}thig and Sieber, {Stephan A.}",

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AU - Lehmann, Johannes

AU - Richers, Johannes

AU - Pöthig, Alexander

AU - Sieber, Stephan A.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.

AB - Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.

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Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

Abstract

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