Synthesis of rac-1-(9-o-carboranyl)nonyl-2-methyl-glycero-3-phosphocholine (B-Et-11-OMe), a potential boron carrier for Boron Neutron Capture Therapy (BNCT)

Peter Lemmen, Birgit Werner

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12 Scopus citations

Abstract

Boron-containing analogues of ether lipids are proposed as boron carriers in the boron neutron capture therapy (BNCT). The synthesis of rac-1-(9-o-Carboranyl)nonyl-2-methyl-glycero- 3-phosphocholine (B-Et-11-OMe) as a first representative is described. The carborane is introduced into the readily assembled glycerol ether moiety. The phosphocholine headgroup is introduced by 2-chloro-3-methyl-1,3,2-λ3-oxazaphospholane using a phosphoamidite strategy and subsequent ring opening under alkylating conditions.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalChemistry and Physics of Lipids
Volume62
Issue number2
DOIs
StatePublished - Sep 1992

Keywords

  • BNCT
  • boron neutron capture therapy
  • ether lipid
  • glycidyl ether
  • phosphoamidite

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