Synthesis of Primary Amines: First Homogeneously Catalyzed Reductive Amination with Ammonia

Thoralf Gross, Abdul Majeed Seayad, Moballigh Ahmad, Matthias Beller

Research output: Contribution to journalArticlepeer-review

233 Scopus citations

Abstract

(Matrix Presented) The synthesis of primary amines via reductive amination of the corresponding carbonyl compounds with aqueous ammonia is achieved for the first time with soluble transition metal complexes. Up to an 86% yield and a 97% selectivity for benzylamines were obtained in the case of various benzaldehydes by using a Rh-catalyst together with water-soluble phosphine and ammonium acetate. In the case of aliphatic aldehydes, a bimetallic catalyst based on Rh/Ir gave improved results.

Original languageEnglish
Pages (from-to)2055-2058
Number of pages4
JournalOrganic Letters
Volume4
Issue number12
DOIs
StatePublished - 13 Jun 2002
Externally publishedYes

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