Synthesis of new N-analogous corollosporine derivatives with antibacterial activity by laccase-catalyzed amination

Annett Mikolasch, Susanne Hessel, Manuela Gesell Salazar, Helfried Neumann, Katrin Manda, Dirk Gördes, Enrico Schmidt, Kerstin Thurow, Elke Hammer, Ulrike Lindequist, Matthias Beller, Frieder Schauer

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Corollosporine isolated from the marine fungus Corollospora maritima and N-analogous corollosporines are antimicrobial substances. Owing to the basic structure of the N-analogous corollosporines, they have become an attractive target for laccase-catalyzed derivatisation. In this regard we report on the straightforward laccase-catalyzed amination of dihydroxylated arenes with N-analogous corollosporines. In biological assays the obtained amination products are more active than the parent compounds.

Original languageEnglish
Pages (from-to)781-786
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

Keywords

  • Biotransformation
  • Corollospora maritima
  • Corollosporine
  • Laccase
  • Resistance

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