Synthesis of new chiral monodentate aminophosphinites and their use in catalytic asymmetric hydrogenations

Kathrin Junge, Günther Oehme, Axel Monsees, Thomas Riermeier, Uwe Dingerdissen, Matthias Beller

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

A general synthesis of chiral 4-amino-4,5-dihydro-3H- dinaphthophosphepines 5a-f is described. The resulting monodentate chiral aminophosphinites have been tested in the rhodium-catalyzed asymmetric hydrogenation of methyl α-acetamidocinnamate and methyl α-acetamidoacrylate. Enantioselectivities up to 96% ee were obtained in the presence of 5a and sodium dodecylsulfonate in toluene.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalJournal of Organometallic Chemistry
Volume675
Issue number1-2
DOIs
StatePublished - 30 May 2003
Externally publishedYes

Keywords

  • Chiral aminophosphinites
  • Enantioselectivities
  • Toluene

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