Synthesis of N-Lauroyl Sarcosine by Amidocarbonylation: Comparing Homogeneous and Heterogeneous Palladium Catalysts

Sören Hancker, Stefanie Kreft, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

An improved system for the synthesis of N-acyl amino acids via Pd-catalyzed amidocarbonylation is reported. Utilizing inexpensive Pd black gives the industrially important surfactant N-lauroyl sarcosine in excellent yields (95%) on a multi-gram scale. Advantages of the new system include reusability, decreased process temperature, and, importantly, drastically decreased co-catalyst loading.

Original languageEnglish
Pages (from-to)2045-2051
Number of pages7
JournalOrganic Process Research and Development
Volume21
Issue number12
DOIs
StatePublished - 15 Dec 2017
Externally publishedYes

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