Synthesis of functional poly(1,4-ketone)s bearing bioactive moieties by Pd-catalyzed insertion polymerization

Violeta Malinova, Bernhard Rieger

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The synthesis of novel alternating polyketones bearing pendent bioactive moieties is presented. These materials were prepared by palladium catalyzed coordination polymerization of carbon monoxide and α-olefins substituted with protected tyrosine or with dipeptide sequences such as tyrosine-glycine, tyrosine-alanine, and tyrosine-valine. Copolymerization experiments of CO with monomers containing vitamin E or testosterone were also successfully performed under mild reaction conditions. The dicationic Pd (II) bis(phoshine) complex [Pd(dppp)-(NCCH3)2](BF4)2 was used as catalyst precursor giving rise to macromolecules with well-defined structures.

Original languageEnglish
Pages (from-to)2931-2936
Number of pages6
JournalBiomacromolecules
Volume7
Issue number11
DOIs
StatePublished - Nov 2006
Externally publishedYes

Fingerprint

Dive into the research topics of 'Synthesis of functional poly(1,4-ketone)s bearing bioactive moieties by Pd-catalyzed insertion polymerization'. Together they form a unique fingerprint.

Cite this