TY - JOUR
T1 - Synthesis of C‐Glycopeptides via Free Radical Addition of Glycosyl Bromides to Dehydroalanine Derivatives
AU - Kessler, Horst
AU - Wittmann, Valentin
AU - Köck, Matthias
AU - Kottenhahn, Matthias
PY - 1992/7
Y1 - 1992/7
N2 - In only one reaction step, nonnatural C‐glycopeptides of type 1 can be obtained (see right, (S) form). This new class of molecules has remarkable properties; their high chemical stability recommends them as potential glycosidase inhibitors. The absolute configuration of the C‐glycopeptides can be elucidated with NMR spectroscopy and molecular dynamics calculations. (R1,R2 = H, OAc, sugar; R3,R4 = protecting group.) (Figure Presented.)
AB - In only one reaction step, nonnatural C‐glycopeptides of type 1 can be obtained (see right, (S) form). This new class of molecules has remarkable properties; their high chemical stability recommends them as potential glycosidase inhibitors. The absolute configuration of the C‐glycopeptides can be elucidated with NMR spectroscopy and molecular dynamics calculations. (R1,R2 = H, OAc, sugar; R3,R4 = protecting group.) (Figure Presented.)
UR - https://www.scopus.com/pages/publications/33748233897
U2 - 10.1002/anie.199209021
DO - 10.1002/anie.199209021
M3 - Article
AN - SCOPUS:33748233897
SN - 0570-0833
VL - 31
SP - 902
EP - 904
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 7
ER -