Synthesis of a new chiral peptide analogue of DNA using ornithine subunits and solid-phase peptide synthesis methodologies

In this paper we describe the synthesis of chiral peptide nucleic acids (PNAs) 1-3 using SPPS methodologies. Starting material for the monomer units was the commercially available amino acid ornithine. L- or D-ornithine and the nucleobase thymine were linked by a carboxymethylene spacer giving the chiral monomers L-7 and D-7. The SPPS was performed according to the Fmoc strategy.