Synthesis of a new chiral peptide analogue of DNA using ornithine subunits and solid-phase peptide synthesis methodologies

Eduardo Lioy, Horst Kessler

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

In this paper we describe the synthesis of chiral peptide nucleic acids (PNAs) 1-3 using SPPS methodologies. Starting material for the monomer units was the commercially available amino acid ornithine. L- or D-ornithine and the nucleobase thymine were linked by a carboxymethylene spacer giving the chiral monomers L-7 and D-7. The SPPS was performed according to the Fmoc strategy.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalLiebigs Annales
Issue number2
DOIs
StatePublished - Feb 1996

Keywords

  • Fmoc strategy
  • Peptide nucleic acid
  • Solid-phase peptide synthesis

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