Abstract
In this paper we describe the synthesis of chiral peptide nucleic acids (PNAs) 1-3 using SPPS methodologies. Starting material for the monomer units was the commercially available amino acid ornithine. L- or D-ornithine and the nucleobase thymine were linked by a carboxymethylene spacer giving the chiral monomers L-7 and D-7. The SPPS was performed according to the Fmoc strategy.
Original language | English |
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Pages (from-to) | 201-204 |
Number of pages | 4 |
Journal | Liebigs Annales |
Issue number | 2 |
DOIs | |
State | Published - Feb 1996 |
Keywords
- Fmoc strategy
- Peptide nucleic acid
- Solid-phase peptide synthesis