Synthesis of a new chiral N,N,N-tridentate pyridinebisimidazoline ligand library and its application in Ru-catalyzed asymmetric epoxidation

Santosh Bhor, Gopinathan Anilkumar, Kin Tse Man, Markus Klawonn, Christian Döbler, Bianca Bitterlich, Anne Grotevendt, Matthias Beller

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

(Chemical Equation Presented) A small ligand library of chiral tridentate N,N,N-pyridinebisimidazolines have been synthesized for the first time. This new class of ligands can be easily tuned and synthesized on multi g-scale. The usefulness of the ligands is shown in the ruthenium-catalyzed asymmetric epoxidation with hydrogen peroxide as oxidant. Excellent yields (>99%) and good enantioselectivities (up to 71% ee) have been obtained for the epoxidation of aromatic olefins.

Original languageEnglish
Pages (from-to)3393-3396
Number of pages4
JournalOrganic Letters
Volume7
Issue number16
DOIs
StatePublished - 4 Aug 2005
Externally publishedYes

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