Synthesis of a conformationally flexible β-hairpin mimetic

Reinhard W. Hoffmann, Ulrich Schopfer, Gerhard Müller, Trixi Brandl

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Rational conformation design led us to a synthesis of the ω-amido-undecenamide 4, which was shown by theoretical means (simulated annealing techniques) and by NMR and IR spectroscopy to have a high tendency to populate a conformation corresponding to a natural β-II′-type hairpin, despite possessing a conformationally fully flexible open-chain backbone.

Original languageEnglish
Pages (from-to)4424-4441
Number of pages18
JournalHelvetica Chimica Acta
Issue number12
StatePublished - 2002
Externally publishedYes


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