Synthesis of 4-substituted 1,5-dihydropyrrol-2-ones and 5,6-dihydro-1H-pyridin-2-ones by Negishi cross-coupling reactions: Short access to the antidepressant (±)-rolipram

Dominik Albrecht, Thorsten Bach

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A straightforward access to the title compounds was established by Pd-catalyzed Negishi cross-coupling reactions of the readily available bromides 3 and 6 with various functionalized zinc reagents (71-97% yield).

Original languageEnglish
Pages (from-to)1557-1560
Number of pages4
JournalSynlett
Issue number10
DOIs
StatePublished - 18 Jun 2007

Keywords

  • Catalysis
  • Cross-coupling
  • Heterocycles
  • Lactams
  • Palladium
  • Zinc

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