Synthesis of 3-(2-N,N-diethylaminoethoxy)indoles as potential 5-HT 6 receptor ligands

Karolin Alex, Nicolle Schwarz, Vivek Khedkar, Iliyas Ali Sayyed, Annegret Tillack, Dirk Michalik, Jörg Holenz, José Luis Díaz, Matthias Beller

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The synthesis of new pharmaceutically interesting 3-(2-N,N- diethylaminoethoxy)indole derivatives is described. Starting from 3-silyloxy-2-methylindoles, deprotection and in situ aminoalkylation provided 3-(2-N,N-diethylaminoethoxy)indoles in good yield. Further sulfonylation of these novel indoles gave access to potential 5-HT6 receptor ligands.

Original languageEnglish
Pages (from-to)1802-1807
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number10
DOIs
StatePublished - 2008
Externally publishedYes

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