Synthesis of α-amino acid amides: Ruthenium-catalyzed amination of α-hydroxy amides

Min Zhang, Sebastian Imm, Sebastian Bähn, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

142 Scopus citations

Abstract

Give me an N: The catalytic amination of α-hydroxy amides with a variety of amines, including anilines, primary and secondary aliphatic amines, and ammonia, yields a wide range of α-amino amides (see scheme). This atom-efficient amination protocol proceeds efficiently in the presence of a commercially available [Ru 3(CO) 12]/DCPE catalyst system.

Original languageEnglish
Pages (from-to)11197-11201
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume50
Issue number47
DOIs
StatePublished - 18 Nov 2011
Externally publishedYes

Keywords

  • amines
  • homogeneous catalysis
  • ruthenium
  • α-amino acid amides
  • α-hydroxy amides

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