Synthesis, characterisation and biological properties of gold(iii) compounds with modified bipyridine and bipyridylamine ligands

Angela Casini, Mariam Celine Diawara, Rosario Scopelliti, Shaik Mohammed Zakeeruddin, Michael Grätzel, Paul J. Dyson

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Square planar gold(iii) complexes that contain functionalised bipyridine ligands of general formula [Au(N⁁N)Cl2][PF6] [where N⁁N = 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine, 4,4′-dimethoxy-2,2′-bipyridine and 4,4′-diamino-2,2′-bipyridine] have been prepared and characterised by NMR spectroscopy and mass spectrometry. Two of the complexes have also been characterised in the solid state by X-ray crystallography. In addition, a gold(iii) compound bearing a dipyridin-2-ylamine ligand was also prepared and characterised. The complexes were found to undergo hydrolysis under pseudo-physiological conditions. Moreover, the complexes showed moderate to good cytotoxicity in vitro towards the A2780 human ovarian carcinoma cell line and the cisplatin resistant variant A2780cisR. Reactivity studies with biomolecules, such as reducing agents, plasmid DNA and a model protein (ubiquitin) were also performed to provide tentative insights into the mode of action of the complexes.

Original languageEnglish
Pages (from-to)2239-2245
Number of pages7
JournalJournal of the Chemical Society. Dalton Transactions
Volume39
Issue number9
DOIs
StatePublished - 16 Feb 2010
Externally publishedYes

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