Synthesis, biological evaluation and radiolabelling by 18F- fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET

S. B. Höfling, S. Maschauer, H. Hübner, P. Gmeiner, H. J. Wester, O. Prante, M. R. Heinrich

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Radical 18F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D3-selective ligand SH 317 ([ 18F]8). SH 317 has been evaluated as a new PET ligand candidate by in vivo experiments.

Original languageEnglish
Pages (from-to)6933-6937
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number23
DOIs
StatePublished - 1 Dec 2010

Keywords

  • 18-Fluorine
  • Dopamine
  • Ligands
  • Positron emission tomography
  • Radiochemical labelling

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