Synthesis and NMR structure of peptidomimetic α4β7-integrin antagonists

Dirk Gottschling; Jürgen Boer; Luciana Marinelli; Georg Voll; Melina Haupt; Anja Schuster; Bernhard Holzmann; Horst Kessler

doi:10.1002/1439-7633(20020603)3:6<575::AID-CBIC575>3.0.CO;2-7

Synthesis and NMR structure of peptidomimetic α4β7-integrin antagonists

Dirk Gottschling, Jürgen Boer, Luciana Marinelli, Georg Voll, Melina Haupt, Anja Schuster, Bernhard Holzmann, Horst Kessler

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Anti-inflammatory drug candidates could result from efforts to reduce the peptidic character of integrin antagonists such as the compound shown in the scheme. Synthesis and NMR spectroscopy structural analysis of peptidomimetics that act as α4β7-integrin antagonists provided important information about the structural and functional requirements of the Leu- Asp-Thr recognition sequence for α4β7 integrins.

Original language	English
Pages (from-to)	575-578
Number of pages	4
Journal	ChemBioChem
Volume	3
Issue number	6
DOIs	https://doi.org/10.1002/1439-7633(20020603)3:6<575::AID-CBIC575>3.0.CO;2-7
State	Published - 2002

Keywords

Drug research
Inhibitors
Medicinal chemistry
Peptidomimetics
Structure elucidation

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10.1002/1439-7633(20020603)3:6<575::AID-CBIC575>3.0.CO;2-7

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title = "Synthesis and NMR structure of peptidomimetic α4β7-integrin antagonists",

abstract = "Anti-inflammatory drug candidates could result from efforts to reduce the peptidic character of integrin antagonists such as the compound shown in the scheme. Synthesis and NMR spectroscopy structural analysis of peptidomimetics that act as α4β7-integrin antagonists provided important information about the structural and functional requirements of the Leu- Asp-Thr recognition sequence for α4β7 integrins.",

keywords = "Drug research, Inhibitors, Medicinal chemistry, Peptidomimetics, Structure elucidation",

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T1 - Synthesis and NMR structure of peptidomimetic α4β7-integrin antagonists

AU - Gottschling, Dirk

AU - Boer, Jürgen

AU - Marinelli, Luciana

AU - Voll, Georg

AU - Haupt, Melina

AU - Schuster, Anja

AU - Holzmann, Bernhard

AU - Kessler, Horst

PY - 2002

Y1 - 2002

N2 - Anti-inflammatory drug candidates could result from efforts to reduce the peptidic character of integrin antagonists such as the compound shown in the scheme. Synthesis and NMR spectroscopy structural analysis of peptidomimetics that act as α4β7-integrin antagonists provided important information about the structural and functional requirements of the Leu- Asp-Thr recognition sequence for α4β7 integrins.

AB - Anti-inflammatory drug candidates could result from efforts to reduce the peptidic character of integrin antagonists such as the compound shown in the scheme. Synthesis and NMR spectroscopy structural analysis of peptidomimetics that act as α4β7-integrin antagonists provided important information about the structural and functional requirements of the Leu- Asp-Thr recognition sequence for α4β7 integrins.

KW - Drug research

KW - Inhibitors

KW - Medicinal chemistry

KW - Peptidomimetics

KW - Structure elucidation

UR - http://www.scopus.com/inward/record.url?scp=0036903912&partnerID=8YFLogxK

U2 - 10.1002/1439-7633(20020603)3:6<575::AID-CBIC575>3.0.CO;2-7

DO - 10.1002/1439-7633(20020603)3:6<575::AID-CBIC575>3.0.CO;2-7

M3 - Article

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AN - SCOPUS:0036903912

SN - 1439-4227

VL - 3

SP - 575

EP - 578

JO - ChemBioChem

JF - ChemBioChem

IS - 6

ER -

Synthesis and NMR structure of peptidomimetic α4β7-integrin antagonists

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Keywords

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