Synthesis and NMR investigation of cyclic pentapeptide analogues of thymopentin

Horst Kessler; Bernhard Kutscher

doi:10.1016/S0040-4039(00)61873-7

Synthesis and NMR investigation of cyclic pentapeptide analogues of thymopentin

Horst Kessler
, Bernhard Kutscher

Johann Wolfgang Goethe University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The synthesis of two cyclic pentapeptides cyclo (-Arg-Lys-Xxx-D-Val-Tyr-) (Xxx=Asp or Glu) with thymopentin-analogue sequences is described. Cyclization was achieved by the carbodiimide/DMAP method. The results of the NMR investigations performed on the protected pentapeptides suggest a βII′/γ-structure in DMSO solution.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Tetrahedron Letters
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/S0040-4039(00)61873-7
State	Published - 1985
Externally published	Yes

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title = "Synthesis and NMR investigation of cyclic pentapeptide analogues of thymopentin",

abstract = "The synthesis of two cyclic pentapeptides cyclo (-Arg-Lys-Xxx-D-Val-Tyr-) (Xxx=Asp or Glu) with thymopentin-analogue sequences is described. Cyclization was achieved by the carbodiimide/DMAP method. The results of the NMR investigations performed on the protected pentapeptides suggest a βII′/γ-structure in DMSO solution.",

author = "Horst Kessler and Bernhard Kutscher",

note = "Funding Information: Acknowledgements: We thank Prof. Schwars for recording the FAB-MS spectra, This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. The biological testing was performed at the Hoechst AG (Dr. R. Obermeier and Dr. H. Mtillner).",

year = "1985",

doi = "10.1016/S0040-4039(00)61873-7",

language = "English",

volume = "26",

pages = "177--180",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "2",

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T1 - Synthesis and NMR investigation of cyclic pentapeptide analogues of thymopentin

AU - Kessler, Horst

AU - Kutscher, Bernhard

N1 - Funding Information: Acknowledgements: We thank Prof. Schwars for recording the FAB-MS spectra, This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. The biological testing was performed at the Hoechst AG (Dr. R. Obermeier and Dr. H. Mtillner).

PY - 1985

Y1 - 1985

N2 - The synthesis of two cyclic pentapeptides cyclo (-Arg-Lys-Xxx-D-Val-Tyr-) (Xxx=Asp or Glu) with thymopentin-analogue sequences is described. Cyclization was achieved by the carbodiimide/DMAP method. The results of the NMR investigations performed on the protected pentapeptides suggest a βII′/γ-structure in DMSO solution.

AB - The synthesis of two cyclic pentapeptides cyclo (-Arg-Lys-Xxx-D-Val-Tyr-) (Xxx=Asp or Glu) with thymopentin-analogue sequences is described. Cyclization was achieved by the carbodiimide/DMAP method. The results of the NMR investigations performed on the protected pentapeptides suggest a βII′/γ-structure in DMSO solution.

UR - https://www.scopus.com/pages/publications/0021932410

U2 - 10.1016/S0040-4039(00)61873-7

DO - 10.1016/S0040-4039(00)61873-7

M3 - Article

AN - SCOPUS:0021932410

SN - 0040-4039

VL - 26

SP - 177

EP - 180

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 2

ER -

Synthesis and NMR investigation of cyclic pentapeptide analogues of thymopentin

Abstract

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