Synthesis and catalytic application of novel binaphthyl-derived phosphorous ligands

Kathrin Junge, Bernhard Hagemann, Stephan Enthaler, Giulia Erre, Matthias Beller

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We describe our recent achievements in the synthesis of chiral phosphorous ligands and their application in catalytic asymmetric hydrogenation reactions. Special attention is given to the development of novel binaphthophosphepine ligands. Starting from enantiomerically pure 1,1′-binaphthol or 2,2′-dimethyl-1,1′-binaphthyl and the building blocks A or B, new chelating P-ligands have been synthesized in one step in good to excellent yields (68-95%). The resulting chiral bidentate phosphines, phosphites and phosphonites were tested in various asymmetric hydrogenation benchmark reactions. Interestingly, small structural changes within the ligands exhibit a significant influence on the enantioselectivity of the hydrogenation reactions.

Original languageEnglish
Pages (from-to)50-66
Number of pages17
JournalArkivoc
Volume2007
Issue number5
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Asymmetric hydrogenation
  • Chiral phosphines
  • Homogeneous catalysis

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