Synthesis and antimicrobial activity of N-analogous corollosporines

Helfried Neumann, Dirk Strübing, Michael Lalk, Stefan Klaus, Sandra Hübner, Anke Spannenberg, Ulrike Lindequist, Matthias Beller

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Corollosporine is an antimicrobial metabolite, which was isolated from the marine fungus Corollospora maritima. Owing to its basic 4-hydroxyphthalic acid anhydride structure, it has become an attractive target for a structure/activity relationship modelling of derived compounds with potential antibiotic activity. In this regard we report on the straightforward synthesis of hetero analogous corollosporines, which were easily prepared by a three-step reaction sequence, taking advantage of a novel multicomponent reaction (AAD-reaction) and a subsequent aromatization/Grignard reaction protocol. Furthermore, the obtained products were tested in several biological assays to evaluate their antimicrobial activity.

Original languageEnglish
Pages (from-to)1365-1375
Number of pages11
JournalOrganic and Biomolecular Chemistry
Issue number7
StatePublished - 2006
Externally publishedYes


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