Synthese und Struktur des Zink(l‐aspartat)chlorids, Zn(L‐AspH)Cl

Hubert Schmidbaur; Ina Bach; Jürgen Riede; Gerhard Müller; Joachim Helbig; Günther Hopf

doi:10.1002/cber.19871200531

Synthese und Struktur des Zink(l‐aspartat)chlorids, Zn(L‐AspH)Cl

Hubert Schmidbaur
, Ina Bach
, Jürgen Riede
, Gerhard Müller
, Joachim Helbig
, Günther Hopf

Department of Chemistry

Technical University of Munich
Wissenschaftliche Abteilung der Verla-Pharm GmbH &Co KG

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The reaction of ZnO or ZnCO₃ with L‐aspartic acid yields zinc di(L‐aspartate), wherein aspartic acid (L‐AspH₂) functions as a monobasic acid: Zn(L‐AspH)₂. This precursor reacts with one equivalent of ZnCl₂ in aqueous solution at pH=4.25 to give the title compound Zn(L‐AspH)Cl, which contains no water of crystallisation (solubility: 12.8% [w/w] at 22°C). The X‐ray structure analysis shows the zinc atoms to be tetrahedrally surrounded by a chloride ion and three oxygen atoms of carboxylate groups originating from three different L‐AspH anions. This constitution is fundamentally different from that of the magnesium analogue, but also of the corresponding halide‐free aspartates and glutamates of zinc and cadmium. The results may be of some significance for pharmacological cooperativity phenomena (chloride/aspartate) in metal complexation.

Original language	German
Pages (from-to)	867-869
Number of pages	3
Journal	Chemische Berichte
Volume	120
Issue number	5
DOIs	https://doi.org/10.1002/cber.19871200531
State	Published - 1987

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title = "Synthese und Struktur des Zink(l‐aspartat)chlorids, Zn(L‐AspH)Cl",

abstract = "The reaction of ZnO or ZnCO3 with L‐aspartic acid yields zinc di(L‐aspartate), wherein aspartic acid (L‐AspH2) functions as a monobasic acid: Zn(L‐AspH)2. This precursor reacts with one equivalent of ZnCl2 in aqueous solution at pH=4.25 to give the title compound Zn(L‐AspH)Cl, which contains no water of crystallisation (solubility: 12.8\% [w/w] at 22°C). The X‐ray structure analysis shows the zinc atoms to be tetrahedrally surrounded by a chloride ion and three oxygen atoms of carboxylate groups originating from three different L‐AspH anions. This constitution is fundamentally different from that of the magnesium analogue, but also of the corresponding halide‐free aspartates and glutamates of zinc and cadmium. The results may be of some significance for pharmacological cooperativity phenomena (chloride/aspartate) in metal complexation.",

author = "Hubert Schmidbaur and Ina Bach and J{\"u}rgen Riede and Gerhard M{\"u}ller and Joachim Helbig and G{\"u}nther Hopf",

year = "1987",

doi = "10.1002/cber.19871200531",

language = "Deutsch",

volume = "120",

pages = "867--869",

journal = "Chemische Berichte",

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TY - JOUR

T1 - Synthese und Struktur des Zink(l‐aspartat)chlorids, Zn(L‐AspH)Cl

AU - Schmidbaur, Hubert

AU - Bach, Ina

AU - Riede, Jürgen

AU - Müller, Gerhard

AU - Helbig, Joachim

AU - Hopf, Günther

PY - 1987

Y1 - 1987

N2 - The reaction of ZnO or ZnCO3 with L‐aspartic acid yields zinc di(L‐aspartate), wherein aspartic acid (L‐AspH2) functions as a monobasic acid: Zn(L‐AspH)2. This precursor reacts with one equivalent of ZnCl2 in aqueous solution at pH=4.25 to give the title compound Zn(L‐AspH)Cl, which contains no water of crystallisation (solubility: 12.8% [w/w] at 22°C). The X‐ray structure analysis shows the zinc atoms to be tetrahedrally surrounded by a chloride ion and three oxygen atoms of carboxylate groups originating from three different L‐AspH anions. This constitution is fundamentally different from that of the magnesium analogue, but also of the corresponding halide‐free aspartates and glutamates of zinc and cadmium. The results may be of some significance for pharmacological cooperativity phenomena (chloride/aspartate) in metal complexation.

AB - The reaction of ZnO or ZnCO3 with L‐aspartic acid yields zinc di(L‐aspartate), wherein aspartic acid (L‐AspH2) functions as a monobasic acid: Zn(L‐AspH)2. This precursor reacts with one equivalent of ZnCl2 in aqueous solution at pH=4.25 to give the title compound Zn(L‐AspH)Cl, which contains no water of crystallisation (solubility: 12.8% [w/w] at 22°C). The X‐ray structure analysis shows the zinc atoms to be tetrahedrally surrounded by a chloride ion and three oxygen atoms of carboxylate groups originating from three different L‐AspH anions. This constitution is fundamentally different from that of the magnesium analogue, but also of the corresponding halide‐free aspartates and glutamates of zinc and cadmium. The results may be of some significance for pharmacological cooperativity phenomena (chloride/aspartate) in metal complexation.

UR - https://www.scopus.com/pages/publications/0001640521

U2 - 10.1002/cber.19871200531

DO - 10.1002/cber.19871200531

M3 - Artikel

AN - SCOPUS:0001640521

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VL - 120

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JO - Chemische Berichte

JF - Chemische Berichte

IS - 5

ER -

Synthese und Struktur des Zink(l‐aspartat)chlorids, Zn(L‐AspH)Cl

Abstract

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