Switching the conformation of a DNA molecule with a chemical oscillator

Tim Liedl; Friedrich C. Simmel

doi:10.1021/nl051180j

Switching the conformation of a DNA molecule with a chemical oscillator

Tim Liedl
, Friedrich C. Simmel

Ludwig-Maximilians-Universität München

Research output: Contribution to journal › Article › peer-review

191 Scopus citations

Abstract

pH oscillations generated by a nonequilibrium chemical reaction are used to switch a pH-sensitive DNA structure between two distinct conformations. The utilization of a chemical oscillator represents a novel method for achieving autonomous motion molecular devices. The oscillatory reaction is a variant of the Landolt reaction and produces pH variations in the range between pH 5 and in this range, a cytosing rich DNA strand can be switched between a random coil conformation and the folded i-motif structure. The coformational changes a monitored simultaneously with the pH value in fluorescence-resonance energy-transfer experiments.

Original language	English
Pages (from-to)	1894-1898
Number of pages	5
Journal	Nano Letters
Volume	5
Issue number	10
DOIs	https://doi.org/10.1021/nl051180j
State	Published - Oct 2005
Externally published	Yes

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10.1021/nl051180j

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title = "Switching the conformation of a DNA molecule with a chemical oscillator",

abstract = "pH oscillations generated by a nonequilibrium chemical reaction are used to switch a pH-sensitive DNA structure between two distinct conformations. The utilization of a chemical oscillator represents a novel method for achieving autonomous motion molecular devices. The oscillatory reaction is a variant of the Landolt reaction and produces pH variations in the range between pH 5 and in this range, a cytosing rich DNA strand can be switched between a random coil conformation and the folded i-motif structure. The coformational changes a monitored simultaneously with the pH value in fluorescence-resonance energy-transfer experiments.",

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AB - pH oscillations generated by a nonequilibrium chemical reaction are used to switch a pH-sensitive DNA structure between two distinct conformations. The utilization of a chemical oscillator represents a novel method for achieving autonomous motion molecular devices. The oscillatory reaction is a variant of the Landolt reaction and produces pH variations in the range between pH 5 and in this range, a cytosing rich DNA strand can be switched between a random coil conformation and the folded i-motif structure. The coformational changes a monitored simultaneously with the pH value in fluorescence-resonance energy-transfer experiments.

UR - https://www.scopus.com/pages/publications/27544503005

U2 - 10.1021/nl051180j

DO - 10.1021/nl051180j

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JO - Nano Letters

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Switching the conformation of a DNA molecule with a chemical oscillator

Abstract

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