Surrounding tissue determinates Dolichos biflorus lectin-affinity of vascular endothelium

J. Plendl, F. Sinowatz, W. Schmahl

Research output: Contribution to journalArticlepeer-review

Abstract

Binding of the lectin Dolichos biflorus agglutinin (DBA) was investigated in normal vascular endothelium of different organs as well as in hemangiomas and hemangiosarcomas in adult NMRI mice. Moreover, DBA-binding of vascular endothelium in normal organs was compared to DBA-binding of vascular endothelium in primary non-vascular tumors and in their metastases in the host organs of metastasis. DBA-binding was found to be organ-specific. Endothelial cells in hemangiomas and in hemangiosarcomas, limited to a single organ, displayed the same DBA-affinity as the normal organ with exception of the liver, here normal DBA-negative endothelium became DBA-positive after malignant transformation. When multiple hemangiosarcomas were present, the DBA-binding pattern was changed as if the metastasizing hemangiosarcomas at the site of metastasis expressed the DBA-affinity of the primary tumor. Blood vessels in benign and in malignant non-endothelial tumors of a specific organ expressed the same endothelial DBA binding. This pattern did not necessarily reappear in metastatic tumors. The DBA-affinities or vascular endothelium in small metastases and host organs were similar, and those in larger metastases identical to those in the primary tumors. Our findings support the hypothesis that the expression of the endothelial DBA-binding site is determined by its surrounding tissue, and may constitute part of the so-called organ- and tissue-address.

Original languageEnglish
Pages (from-to)3-17
Number of pages15
JournalElectronic Journal of Pathology and Histology
Volume1
Issue number1
StatePublished - 1995
Externally publishedYes

Keywords

  • Dolichos biflorus lectin
  • Endothelium
  • Metastasis
  • NMRI mouse
  • Neoplasm

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