68Ga-PSMA PET/MR with multimodality image analysis for primary prostate cancer

Matthias Eiber; Stephan G. Nekolla; Tobias Maurer; Gregor Weirich; Hans Jürgen Wester; Markus Schwaiger

doi:10.1007/s00261-014-0301-z

⁶⁸Ga-PSMA PET/MR with multimodality image analysis for primary prostate cancer

Matthias Eiber, Stephan G. Nekolla, Tobias Maurer, Gregor Weirich, Hans Jürgen Wester, Markus Schwaiger

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Technical University of Munich

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72 Scopus citations

Abstract

Current imaging procedures for prostate cancer including positron emission tomography (PET) exhibit considerable limitations and are not always able to meet the diagnostic needs. Recently, a ⁶⁸Gallium-labeled ligand of the prostate-specific membrane antigen (⁶⁸Ga-PSMA) has been introduced in PET-imaging of prostate cancer with first promising results. Due to relatively exclusive expression of PSMA in prostatic tissue as well as increased expression in prostate cancer, 68 Ga-PSMA was reported to exhibit a favorable lesion to background ratio. Together with the novel development of combined PET/MRI, the combination of excellent morphological detail, multiparametric functional information, and molecular PET data might lead to a significant improvement in detection of prostate cancer. We present an exemplarily case of primary staging using multiparametric ⁶⁸Ga-PSMA PET/MR by combining molecular and structural information.

Original language	English
Pages (from-to)	1769-1771
Number of pages	3
Journal	Abdominal Imaging
Volume	40
Issue number	6
DOIs	https://doi.org/10.1007/s00261-014-0301-z
State	Published - 12 Aug 2015

Keywords

Ga-PSMA
Multiparametric analysis
PET/MR
Prostate cancer
Tumor biology

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title = "68Ga-PSMA PET/MR with multimodality image analysis for primary prostate cancer",

abstract = "Current imaging procedures for prostate cancer including positron emission tomography (PET) exhibit considerable limitations and are not always able to meet the diagnostic needs. Recently, a 68Gallium-labeled ligand of the prostate-specific membrane antigen (68Ga-PSMA) has been introduced in PET-imaging of prostate cancer with first promising results. Due to relatively exclusive expression of PSMA in prostatic tissue as well as increased expression in prostate cancer, 68 Ga-PSMA was reported to exhibit a favorable lesion to background ratio. Together with the novel development of combined PET/MRI, the combination of excellent morphological detail, multiparametric functional information, and molecular PET data might lead to a significant improvement in detection of prostate cancer. We present an exemplarily case of primary staging using multiparametric 68Ga-PSMA PET/MR by combining molecular and structural information.",

keywords = "Ga-PSMA, Multiparametric analysis, PET/MR, Prostate cancer, Tumor biology",

author = "Matthias Eiber and Nekolla, {Stephan G.} and Tobias Maurer and Gregor Weirich and Wester, {Hans J{\"u}rgen} and Markus Schwaiger",

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doi = "10.1007/s00261-014-0301-z",

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T1 - 68Ga-PSMA PET/MR with multimodality image analysis for primary prostate cancer

AU - Eiber, Matthias

AU - Nekolla, Stephan G.

AU - Maurer, Tobias

AU - Weirich, Gregor

AU - Wester, Hans Jürgen

AU - Schwaiger, Markus

PY - 2015/8/12

Y1 - 2015/8/12

N2 - Current imaging procedures for prostate cancer including positron emission tomography (PET) exhibit considerable limitations and are not always able to meet the diagnostic needs. Recently, a 68Gallium-labeled ligand of the prostate-specific membrane antigen (68Ga-PSMA) has been introduced in PET-imaging of prostate cancer with first promising results. Due to relatively exclusive expression of PSMA in prostatic tissue as well as increased expression in prostate cancer, 68 Ga-PSMA was reported to exhibit a favorable lesion to background ratio. Together with the novel development of combined PET/MRI, the combination of excellent morphological detail, multiparametric functional information, and molecular PET data might lead to a significant improvement in detection of prostate cancer. We present an exemplarily case of primary staging using multiparametric 68Ga-PSMA PET/MR by combining molecular and structural information.

AB - Current imaging procedures for prostate cancer including positron emission tomography (PET) exhibit considerable limitations and are not always able to meet the diagnostic needs. Recently, a 68Gallium-labeled ligand of the prostate-specific membrane antigen (68Ga-PSMA) has been introduced in PET-imaging of prostate cancer with first promising results. Due to relatively exclusive expression of PSMA in prostatic tissue as well as increased expression in prostate cancer, 68 Ga-PSMA was reported to exhibit a favorable lesion to background ratio. Together with the novel development of combined PET/MRI, the combination of excellent morphological detail, multiparametric functional information, and molecular PET data might lead to a significant improvement in detection of prostate cancer. We present an exemplarily case of primary staging using multiparametric 68Ga-PSMA PET/MR by combining molecular and structural information.

KW - Ga-PSMA

KW - Multiparametric analysis

KW - PET/MR

KW - Prostate cancer

KW - Tumor biology

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JO - Abdominal Imaging

JF - Abdominal Imaging

IS - 6

ER -

⁶⁸Ga-PSMA PET/MR with multimodality image analysis for primary prostate cancer

Abstract

Keywords

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