⁶⁸Ga-PSMA-HBED-CC Uptake in Cervical, Celiac, and Sacral Ganglia as an Important Pitfall in Prostate Cancer PET Imaging

The study aims to investigate the presence of physiologic prostatespecific membrane antigen (⁶⁸Ga-PSMA)-ligand uptake on PET in cervical, celiac, and sacral ganglia of the sympathetic trunk as a pitfall for lymph node metastases in prostate cancer imaging. Methods: Four hundred seven patients who underwent Glu-NH-CO-NH-Lys radiolabeled with ⁶⁸Ga-gallium N,N-bis[2-hydroxy-5-(carboxyethyl) benzyl]ethylenediamine-N,N-diacetic acid (⁶⁸Ga-PSMA-HBED-CC) PET (combined with a diagnostic CT) were retrospectively analyzed. The number of ⁶⁸Ga-PSMA PET-positive cervical, celiac, and sacral ganglia was determined, and the configuration and SUVmax of each ganglion were measured. In addition, the configuration and SUVmax of adjacent lymph node metastases in the respective region (cervical, celiac, or sacral) were determined. Results: ⁶⁸Ga-PSMA-ligand uptake above background was detected in 401 (98.5%) patients in any peripheral ganglia, in 369 (92%) patients in cervical ganglia, in 363 (89%) patients in celiac ganglia, and in ¹⁸3 (46%) patients in sacral ganglia. The ⁶⁸Ga-PSMA-ligand uptake was highest in celiac (mean SUVmax, 2.9 ± 0.8 vs. cervical mean SUV_max, 2.4 ± 0.6) and sacral (mean SUV_max 1.7 ± 0.5; both P < 0.0001) ganglia. Intraindividually there was a statistically significant but weak to moderate correlation between the ⁶⁸Ga-PSMA-ligand uptake in cervical versus celiac ganglia (R = 0.34, P < 0.0001), cervical versus sacral (R = 0.52, P < 0.0001), and celiac versus sacral (R = 0.16, P < 0.05). The ⁶⁸Ga-PSMA-ligand uptake was significantlymore intense in adjacent lymph node metastases than the respective ganglia (cervical: ¹⁸.0 ± 16.2 vs. 2.4 ± 0.6, P < 0.0001; celiac: 13.5 ± 12.3 vs. 2.9 ± 0.8, P < 0.0001; sacral: 13.4 ± 11.6 vs. 1.7 ± 0.5, P < 0.0001). Furthermore, ganglia predominantly exhibit a band-shaped configuration (71.2%), followed by a teardrop (26.8%) and only rarely a nodular configuration (2.0%). Conversely, lymph node metastases are only rarely band-shaped (1.1%), but more often show teardrop (40.3%) or nodular appearance (58.6%) (P < 0.00001). Conclusion: ⁶⁸Ga-PSMA-ligand uptake in ganglia along the sympathetic trunk as assessed by ⁶⁸Ga-PSMA-HBED-CC PET represents an important pitfall in prostate cancer PET imaging. The ⁶⁸Ga-PSMA-ligand uptake is higher in celiac ganglia than cervical or sacral ganglia, and the level of ⁶⁸Ga-PSMA-ligand uptake seems to be patient-related. For the differentiation between lymph node metastases and sympathetic ganglia, both intensity of ⁶⁸Ga-PSMA-ligand uptake and exact localization and configuration of the respective lesion should be examined carefully.