TY - JOUR
T1 - [68Ga]-Albumin-PET in the monitoring of left ventricular function in murine models of ischemic and dilated cardiomyopathy
T2 - Comparison with cardiac MRI
AU - Todica, Andrei
AU - Brunner, Stefan
AU - Böning, Guido
AU - Lehner, Sebastian
AU - Nekolla, Stephan G.
AU - Wildgruber, Moritz
AU - Übleis, Christopher
AU - Wängler, Carmen
AU - Sauter, Martina
AU - Klingel, Karin
AU - Cumming, Paul
AU - Bartenstein, Peter
AU - Schirrmacher, Ralf
AU - Franz, Wolfgang Michael
AU - Hacker, Marcus
N1 - Funding Information:
Acknowledgements. Financial support was provided by the Fritz-Bender-Stiftung and the Else Kröner-Fresenius-Stiftung.
PY - 2013/8
Y1 - 2013/8
N2 - Purpose: The purpose of this study is to evaluate left ventricular functional parameters in healthy mice and in different murine models of cardiomyopathy with the novel blood pool (BP) positron emission tomography (PET) tracer [68Ga]-albumin. Procedures: ECG-gated microPET examinations were obtained in healthy mice, and mice with dilative (DCM) and ischemic cardiomyopathy (ICM) using the novel BP tracer [68Ga]-albumin (AlbBP), as well as [18F]-FDG microPET. Cine-magnetic resonance imaging (MRI) examination performed on a clinical 1.5-T MRI provided the reference standard measurements. Results: When considering the combined group of healthy controls, DCM and ICM AlbBP-PET significantly overestimated the magnitudes of EDV (AlbBP, 181 ± 86 μl; cine-MRI, 125 ± 80 μl; P < 0.001) and ESV (AlbBP, 136 ± 92 μl; cine-MRI, 96 ± 77 μl; P < 0.001), whereas the EF (AlbBP, 31 ± 16 %; cine-MRI, 33 ± 21 %; P = 0.910) matched closely to cine-MRI results, as did findings with [18F]-FDG. High correlations were found between the measured cardiac parameters (EDV: R = 0.978, ESV: R = 0.989, and LVEF: R = 0.992). Conclusions: Measuring left ventricular function in mice with [68Ga]-albumin BP PET is feasible and showed a high correlation compared to cine-MRI, which was used as a reference standard.
AB - Purpose: The purpose of this study is to evaluate left ventricular functional parameters in healthy mice and in different murine models of cardiomyopathy with the novel blood pool (BP) positron emission tomography (PET) tracer [68Ga]-albumin. Procedures: ECG-gated microPET examinations were obtained in healthy mice, and mice with dilative (DCM) and ischemic cardiomyopathy (ICM) using the novel BP tracer [68Ga]-albumin (AlbBP), as well as [18F]-FDG microPET. Cine-magnetic resonance imaging (MRI) examination performed on a clinical 1.5-T MRI provided the reference standard measurements. Results: When considering the combined group of healthy controls, DCM and ICM AlbBP-PET significantly overestimated the magnitudes of EDV (AlbBP, 181 ± 86 μl; cine-MRI, 125 ± 80 μl; P < 0.001) and ESV (AlbBP, 136 ± 92 μl; cine-MRI, 96 ± 77 μl; P < 0.001), whereas the EF (AlbBP, 31 ± 16 %; cine-MRI, 33 ± 21 %; P = 0.910) matched closely to cine-MRI results, as did findings with [18F]-FDG. High correlations were found between the measured cardiac parameters (EDV: R = 0.978, ESV: R = 0.989, and LVEF: R = 0.992). Conclusions: Measuring left ventricular function in mice with [68Ga]-albumin BP PET is feasible and showed a high correlation compared to cine-MRI, which was used as a reference standard.
KW - Albumin
KW - Cardiomyopathy
KW - Ejection fraction
KW - Magnetic resonance imaging
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=84880328540&partnerID=8YFLogxK
U2 - 10.1007/s11307-013-0618-y
DO - 10.1007/s11307-013-0618-y
M3 - Article
C2 - 23408338
AN - SCOPUS:84880328540
SN - 1536-1632
VL - 15
SP - 441
EP - 449
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
IS - 4
ER -
