11C-Choline PET/pathology image coregistration in primary localized prostate cancer

Anca Ligia Grosu; Gregor Weirich; Christina Wendl; Vesna Prokic; Simon Kirste; Hans Geinitz; Michael Souvatzoglou; Juergen E. Gschwend; Markus Schwaiger; Michael Molls; Wolfgang A. Weber; Uwe Treiber; Bernd Joachim Krause

doi:10.1007/s00259-014-2861-0

¹¹C-Choline PET/pathology image coregistration in primary localized prostate cancer

Anca Ligia Grosu
, Gregor Weirich
, Christina Wendl
, Vesna Prokic
, Simon Kirste
, Hans Geinitz
, Michael Souvatzoglou
, Juergen E. Gschwend
, Markus Schwaiger
, Michael Molls
, Wolfgang A. Weber
, Uwe Treiber
, Bernd Joachim Krause

Albert-Ludwigs-Universität Freiburg
Technical University of Munich
Weill Cornell Medical College
University of Rostock

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Results: PET/pathology image coregistration was satisfactory. Mean SUVmax in the TVP was lower than in the NP: 5.0 and 5.5, respectively (p = 0.093). Considering the entire prostate, SUVmax was located in the TVP in two patients, in the TVP and NP in 12 patients and exclusively in NP in 14 patients. Partial overlap the TVP and GTV-PET was seen in 71 % of patients, and complete overlap in 4 %.

Purpose: The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of ¹¹C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC).

Methods: In 28 PC patients, ¹¹C-choline PET/CT was performed before surgery. PET/CT data were coregistered with the pathology specimens. GTV on PET images (GTV-PET) was outlined automatically and corrected manually. Tumour volume in the prostate (TVP) was delineated manually on the pathology specimens. Based on the coregistered PET/pathology images, the following parameters were assessed: SUVmax and SUVmean in the tumoral and nontumoral prostate (NP), GTV-PET (millilitres) and TVP (millilitres).

Conclusion: PET/pathology image coregistration can be used for evaluation of different imaging modalities. ¹¹C-Choline PET failed to distinguish tumour from nontumour tissue.

Original language	English
Pages (from-to)	2242-2248
Number of pages	7
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	41
Issue number	12
DOIs	https://doi.org/10.1007/s00259-014-2861-0
State	Published - Dec 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

PET/pathology image coregistration
Prostate cancer

Access to Document

10.1007/s00259-014-2861-0

Cite this

Grosu, A. L., Weirich, G., Wendl, C., Prokic, V., Kirste, S., Geinitz, H., Souvatzoglou, M., Gschwend, J. E., Schwaiger, M., Molls, M., Weber, W. A., Treiber, U., & Krause, B. J. (2014). ¹¹C-Choline PET/pathology image coregistration in primary localized prostate cancer. European Journal of Nuclear Medicine and Molecular Imaging, 41(12), 2242-2248. https://doi.org/10.1007/s00259-014-2861-0

@article{37213807399845b4ae973beaf8150954,

title = "11C-Choline PET/pathology image coregistration in primary localized prostate cancer",

abstract = "Results: PET/pathology image coregistration was satisfactory. Mean SUVmax in the TVP was lower than in the NP: 5.0 and 5.5, respectively (p = 0.093). Considering the entire prostate, SUVmax was located in the TVP in two patients, in the TVP and NP in 12 patients and exclusively in NP in 14 patients. Partial overlap the TVP and GTV-PET was seen in 71 \% of patients, and complete overlap in 4 \%.Purpose: The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of 11C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC).Methods: In 28 PC patients, 11C-choline PET/CT was performed before surgery. PET/CT data were coregistered with the pathology specimens. GTV on PET images (GTV-PET) was outlined automatically and corrected manually. Tumour volume in the prostate (TVP) was delineated manually on the pathology specimens. Based on the coregistered PET/pathology images, the following parameters were assessed: SUVmax and SUVmean in the tumoral and nontumoral prostate (NP), GTV-PET (millilitres) and TVP (millilitres).Conclusion: PET/pathology image coregistration can be used for evaluation of different imaging modalities. 11C-Choline PET failed to distinguish tumour from nontumour tissue.",

keywords = "PET/pathology image coregistration, Prostate cancer",

author = "Grosu, \{Anca Ligia\} and Gregor Weirich and Christina Wendl and Vesna Prokic and Simon Kirste and Hans Geinitz and Michael Souvatzoglou and Gschwend, \{Juergen E.\} and Markus Schwaiger and Michael Molls and Weber, \{Wolfgang A.\} and Uwe Treiber and Krause, \{Bernd Joachim\}",

note = "Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Berlin Heidelberg.",

year = "2014",

month = dec,

doi = "10.1007/s00259-014-2861-0",

language = "English",

volume = "41",

pages = "2242--2248",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer",

number = "12",

}

Grosu, AL, Weirich, G, Wendl, C, Prokic, V, Kirste, S, Geinitz, H, Souvatzoglou, M, Gschwend, JE , Schwaiger, M , Molls, M , Weber, WA, Treiber, U & Krause, BJ 2014, '¹¹C-Choline PET/pathology image coregistration in primary localized prostate cancer', European Journal of Nuclear Medicine and Molecular Imaging, vol. 41, no. 12, pp. 2242-2248. https://doi.org/10.1007/s00259-014-2861-0

TY - JOUR

T1 - 11C-Choline PET/pathology image coregistration in primary localized prostate cancer

AU - Grosu, Anca Ligia

AU - Weirich, Gregor

AU - Wendl, Christina

AU - Prokic, Vesna

AU - Kirste, Simon

AU - Geinitz, Hans

AU - Souvatzoglou, Michael

AU - Gschwend, Juergen E.

AU - Schwaiger, Markus

AU - Molls, Michael

AU - Weber, Wolfgang A.

AU - Treiber, Uwe

AU - Krause, Bernd Joachim

PY - 2014/12

Y1 - 2014/12

N2 - Results: PET/pathology image coregistration was satisfactory. Mean SUVmax in the TVP was lower than in the NP: 5.0 and 5.5, respectively (p = 0.093). Considering the entire prostate, SUVmax was located in the TVP in two patients, in the TVP and NP in 12 patients and exclusively in NP in 14 patients. Partial overlap the TVP and GTV-PET was seen in 71 % of patients, and complete overlap in 4 %.Purpose: The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of 11C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC).Methods: In 28 PC patients, 11C-choline PET/CT was performed before surgery. PET/CT data were coregistered with the pathology specimens. GTV on PET images (GTV-PET) was outlined automatically and corrected manually. Tumour volume in the prostate (TVP) was delineated manually on the pathology specimens. Based on the coregistered PET/pathology images, the following parameters were assessed: SUVmax and SUVmean in the tumoral and nontumoral prostate (NP), GTV-PET (millilitres) and TVP (millilitres).Conclusion: PET/pathology image coregistration can be used for evaluation of different imaging modalities. 11C-Choline PET failed to distinguish tumour from nontumour tissue.

AB - Results: PET/pathology image coregistration was satisfactory. Mean SUVmax in the TVP was lower than in the NP: 5.0 and 5.5, respectively (p = 0.093). Considering the entire prostate, SUVmax was located in the TVP in two patients, in the TVP and NP in 12 patients and exclusively in NP in 14 patients. Partial overlap the TVP and GTV-PET was seen in 71 % of patients, and complete overlap in 4 %.Purpose: The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of 11C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC).Methods: In 28 PC patients, 11C-choline PET/CT was performed before surgery. PET/CT data were coregistered with the pathology specimens. GTV on PET images (GTV-PET) was outlined automatically and corrected manually. Tumour volume in the prostate (TVP) was delineated manually on the pathology specimens. Based on the coregistered PET/pathology images, the following parameters were assessed: SUVmax and SUVmean in the tumoral and nontumoral prostate (NP), GTV-PET (millilitres) and TVP (millilitres).Conclusion: PET/pathology image coregistration can be used for evaluation of different imaging modalities. 11C-Choline PET failed to distinguish tumour from nontumour tissue.

KW - PET/pathology image coregistration

KW - Prostate cancer

UR - https://www.scopus.com/pages/publications/84919919365

U2 - 10.1007/s00259-014-2861-0

DO - 10.1007/s00259-014-2861-0

M3 - Article

C2 - 25186430

AN - SCOPUS:84919919365

SN - 1619-7070

VL - 41

SP - 2242

EP - 2248

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 12

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