Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials

Owen Martyn Bendor-Samuel, Tabitha Wishlade, Louise Willis, Parvinder Aley, Edward Choi, Rachel Craik, Yama Mujadidi, Ginny Mounce, Fenella Roseman, Arancha De La Horra Gozalo, James Bland, Nazia Taj, Ian Smith, Anette Gabriele Ziegler, Ezio Bonifacio, Christiane Winkler, Florian Haupt, John A. Todd, Laurent Servais, Matthew D. SnapeManu Vatish

Research output: Contribution to journalArticlepeer-review

Abstract

Objective INGR1D (INvestigating Genetic Risk for type 1 Diabetes) was a type 1 diabetes (T1D) genetic screening study established to identify participants for a primary prevention trial (POInT, Primary Oral Insulin Trial). Methods The majority of participants were recruited by research midwives in antenatal clinics from 18 weeks' gestation. Using the NHS Newborn Bloodspot Screening Programme (NBSP) infrastructure, participants enrolled in INGR1D had an extra sample taken from their day 5 bloodspot card sent for T1D genetic screening. Those at an increased risk of T1D were informed of the result, given education about T1D and the opportunity to take part in POInT. Results Between April 2018 and November 2020, 66% of women approached about INGR1D chose to participate. 15 660 babies were enrolled into INGR1D and 14 731 blood samples were processed. Of the processed samples, 157 (1%) had confirmed positive results, indicating an increased risk of T1D, of whom a third (n=49) enrolled into POInT (20 families were unable to participate in POInT due to COVID-19 lockdown restrictions). Conclusion The use of prospective consent to perform personalised genetic testing on samples obtained through the routine NBSP represents a novel mechanism for clinical genetic research in the UK and provides a model for further population-based genetic studies in the newborn.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalArchives of Disease in Childhood
Volume108
Issue number1
DOIs
StatePublished - 28 Sep 2022
Externally publishedYes

Keywords

  • endocrinology
  • genetics
  • neonatology
  • paediatrics

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