Subthalamic nucleus stimulation affects a frontotemporal network: A PET study

Ulrike Schroeder; Andreas Kuehler; Klaus W. Lange; Bernhard Haslinger; Volker M. Tronnier; Martin Krause; Robert Pfister; Henning Boecker; Andres O. Ceballos-Baumann

doi:10.1002/ana.10683

Subthalamic nucleus stimulation affects a frontotemporal network: A PET study

Ulrike Schroeder
, Andreas Kuehler
, Klaus W. Lange
, Bernhard Haslinger
, Volker M. Tronnier
, Martin Krause
, Robert Pfister
, Henning Boecker
, Andres O. Ceballos-Baumann

Department of Neurology

Technical University of Munich
University of Regensburg
Heidelberg University
University Hospital Augsburg

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an effective strategy in the treatment of motor symptoms in advanced Parkinson's disease. However, clinical studies have shown that DBS can affect verbal fluency. Seven Parkinson's disease patients with bilateral DBS of the STN were studied with positron emission tomography (PET) to investigate the effects of STN stimulation on regional cerebral blood flow during a verbal fluency task. Activation of the right orbitofrontal cortex and verbal fluency-associated activation within a left-sided frontotemporal network were decreased during STN stimulation compared with the OFF state. Our results offer an explanation for the commonest neuropsychological side effect of STN stimulation and show that STN stimulation affects a frontotemporal network during a fluency task.

Original language	English
Pages (from-to)	445-450
Number of pages	6
Journal	Annals of Neurology
Volume	54
Issue number	4
DOIs	https://doi.org/10.1002/ana.10683
State	Published - 1 Oct 2003

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title = "Subthalamic nucleus stimulation affects a frontotemporal network: A PET study",

abstract = "Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an effective strategy in the treatment of motor symptoms in advanced Parkinson's disease. However, clinical studies have shown that DBS can affect verbal fluency. Seven Parkinson's disease patients with bilateral DBS of the STN were studied with positron emission tomography (PET) to investigate the effects of STN stimulation on regional cerebral blood flow during a verbal fluency task. Activation of the right orbitofrontal cortex and verbal fluency-associated activation within a left-sided frontotemporal network were decreased during STN stimulation compared with the OFF state. Our results offer an explanation for the commonest neuropsychological side effect of STN stimulation and show that STN stimulation affects a frontotemporal network during a fluency task.",

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T1 - Subthalamic nucleus stimulation affects a frontotemporal network

T2 - A PET study

AU - Schroeder, Ulrike

AU - Kuehler, Andreas

AU - Lange, Klaus W.

AU - Haslinger, Bernhard

AU - Tronnier, Volker M.

AU - Krause, Martin

AU - Pfister, Robert

AU - Boecker, Henning

AU - Ceballos-Baumann, Andres O.

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Y1 - 2003/10/1

N2 - Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an effective strategy in the treatment of motor symptoms in advanced Parkinson's disease. However, clinical studies have shown that DBS can affect verbal fluency. Seven Parkinson's disease patients with bilateral DBS of the STN were studied with positron emission tomography (PET) to investigate the effects of STN stimulation on regional cerebral blood flow during a verbal fluency task. Activation of the right orbitofrontal cortex and verbal fluency-associated activation within a left-sided frontotemporal network were decreased during STN stimulation compared with the OFF state. Our results offer an explanation for the commonest neuropsychological side effect of STN stimulation and show that STN stimulation affects a frontotemporal network during a fluency task.

AB - Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an effective strategy in the treatment of motor symptoms in advanced Parkinson's disease. However, clinical studies have shown that DBS can affect verbal fluency. Seven Parkinson's disease patients with bilateral DBS of the STN were studied with positron emission tomography (PET) to investigate the effects of STN stimulation on regional cerebral blood flow during a verbal fluency task. Activation of the right orbitofrontal cortex and verbal fluency-associated activation within a left-sided frontotemporal network were decreased during STN stimulation compared with the OFF state. Our results offer an explanation for the commonest neuropsychological side effect of STN stimulation and show that STN stimulation affects a frontotemporal network during a fluency task.

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JO - Annals of Neurology

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IS - 4

ER -

Subthalamic nucleus stimulation affects a frontotemporal network: A PET study

Abstract

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