TY - JOUR
T1 - Studies on the chemical identity and biological functions of pangamic acid
AU - Schneider, Dagmar
AU - Helwig, Veronika
AU - Staniek, Katrin
AU - Nohl, Hans
AU - Elstner, Erich F.
PY - 1999
Y1 - 1999
N2 - Pangamic acid (6-O-(dimethylaminoacetyl)-D-gluconic acid) has been detected 1938 and described as a natural, universally occurring substance with multiple biological and medical functions. In this respect pangamic acid has been worldwide on the market since decades as a drug stimulating cellular respiration. In addition to the natural pangamic acid, diisopropylammonium dichloroacetate (DIPA), a synthetic product not found in biological material, is on the market requesting similar biological functions. In commercially available drugs on the German market declared as pangamic acid three separate substances can be found by chemical identification of pangamic acid, namely: gluconic acid, glycine and diisopropylammonium dichloroacetate. As biological functions have been found in vitro inhibition of Cu-dependent LDL oxidation by glycine due to chelation of Cu2+ ions and deterioration of mitochondrial respiratory control due to an increased state IV oxygen consumption rate at high concentrations of DIPA.
AB - Pangamic acid (6-O-(dimethylaminoacetyl)-D-gluconic acid) has been detected 1938 and described as a natural, universally occurring substance with multiple biological and medical functions. In this respect pangamic acid has been worldwide on the market since decades as a drug stimulating cellular respiration. In addition to the natural pangamic acid, diisopropylammonium dichloroacetate (DIPA), a synthetic product not found in biological material, is on the market requesting similar biological functions. In commercially available drugs on the German market declared as pangamic acid three separate substances can be found by chemical identification of pangamic acid, namely: gluconic acid, glycine and diisopropylammonium dichloroacetate. As biological functions have been found in vitro inhibition of Cu-dependent LDL oxidation by glycine due to chelation of Cu2+ ions and deterioration of mitochondrial respiratory control due to an increased state IV oxygen consumption rate at high concentrations of DIPA.
KW - 6-O-(Dimethylaminoacetyl)-D-gluconic acid
KW - Diisopropylammonium dichloroacetate
KW - Gluconic acid
KW - Glycine
KW - Pangamic acid, biological functions, chemical identity
UR - http://www.scopus.com/inward/record.url?scp=0032894455&partnerID=8YFLogxK
U2 - 10.1055/s-0031-1300424
DO - 10.1055/s-0031-1300424
M3 - Article
C2 - 10337453
AN - SCOPUS:0032894455
SN - 0004-4172
VL - 49
SP - 335
EP - 343
JO - Arzneimittel-Forschung/Drug Research
JF - Arzneimittel-Forschung/Drug Research
IS - 4
ER -