Studies of fatty acid metabolism with positron emission tomography in patients with cardiomyopathy

H. Sochor; H. R. Schelbert; M. Schwaiger; E. Henze; M. E. Phelps

doi:10.1007/BF00258110

Studies of fatty acid metabolism with positron emission tomography in patients with cardiomyopathy

H. Sochor, H. R. Schelbert, M. Schwaiger, E. Henze, M. E. Phelps

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41 Scopus citations

Abstract

Positron emission tomography (PET) permits in vivo as well as noninvasive study of fatty acid metabolism. Parameters of ¹¹C-palmitate kinetics relate to the oxidation of fatty acids, and palmitic acid uptake is impaired in patients with coronary disease and cardiomyopathy. Normal myocardium shows homogenous fatty acid·metabolism and can resort to alternate substrates. Diseased myocardium exhibits regional heterogeneity in fatty acid uptake and utilization. In patients with cardiomyopathy, distinct patterns of fatty acid metabolism can be observed following changes of substrate availability by application of an oral glucose load. This intervention also enhances the heterogeneity of ¹¹C-palmitic acid (CPA) uptake and clearance. Thus, PET studies with CPA permit the noninvasive demonstration of effects on substrate availability and may help to characterize patients with ventricular dysfunction on the biochemical level.

Original language	English
Pages (from-to)	S66-S69
Journal	European Journal of Nuclear Medicine
Volume	12
Issue number	1 Supplement
DOIs	https://doi.org/10.1007/BF00258110
State	Published - Aug 1986
Externally published	Yes

Keywords

C-palmitate
Cardiomyopathy
Positron emission tomography

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10.1007/BF00258110

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title = "Studies of fatty acid metabolism with positron emission tomography in patients with cardiomyopathy",

abstract = "Positron emission tomography (PET) permits in vivo as well as noninvasive study of fatty acid metabolism. Parameters of 11C-palmitate kinetics relate to the oxidation of fatty acids, and palmitic acid uptake is impaired in patients with coronary disease and cardiomyopathy. Normal myocardium shows homogenous fatty acid·metabolism and can resort to alternate substrates. Diseased myocardium exhibits regional heterogeneity in fatty acid uptake and utilization. In patients with cardiomyopathy, distinct patterns of fatty acid metabolism can be observed following changes of substrate availability by application of an oral glucose load. This intervention also enhances the heterogeneity of 11C-palmitic acid (CPA) uptake and clearance. Thus, PET studies with CPA permit the noninvasive demonstration of effects on substrate availability and may help to characterize patients with ventricular dysfunction on the biochemical level.",

keywords = "C-palmitate, Cardiomyopathy, Positron emission tomography",

author = "H. Sochor and Schelbert, {H. R.} and M. Schwaiger and E. Henze and Phelps, {M. E.}",

year = "1986",

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AU - Sochor, H.

AU - Schelbert, H. R.

AU - Schwaiger, M.

AU - Henze, E.

AU - Phelps, M. E.

PY - 1986/8

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N2 - Positron emission tomography (PET) permits in vivo as well as noninvasive study of fatty acid metabolism. Parameters of 11C-palmitate kinetics relate to the oxidation of fatty acids, and palmitic acid uptake is impaired in patients with coronary disease and cardiomyopathy. Normal myocardium shows homogenous fatty acid·metabolism and can resort to alternate substrates. Diseased myocardium exhibits regional heterogeneity in fatty acid uptake and utilization. In patients with cardiomyopathy, distinct patterns of fatty acid metabolism can be observed following changes of substrate availability by application of an oral glucose load. This intervention also enhances the heterogeneity of 11C-palmitic acid (CPA) uptake and clearance. Thus, PET studies with CPA permit the noninvasive demonstration of effects on substrate availability and may help to characterize patients with ventricular dysfunction on the biochemical level.

AB - Positron emission tomography (PET) permits in vivo as well as noninvasive study of fatty acid metabolism. Parameters of 11C-palmitate kinetics relate to the oxidation of fatty acids, and palmitic acid uptake is impaired in patients with coronary disease and cardiomyopathy. Normal myocardium shows homogenous fatty acid·metabolism and can resort to alternate substrates. Diseased myocardium exhibits regional heterogeneity in fatty acid uptake and utilization. In patients with cardiomyopathy, distinct patterns of fatty acid metabolism can be observed following changes of substrate availability by application of an oral glucose load. This intervention also enhances the heterogeneity of 11C-palmitic acid (CPA) uptake and clearance. Thus, PET studies with CPA permit the noninvasive demonstration of effects on substrate availability and may help to characterize patients with ventricular dysfunction on the biochemical level.

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Studies of fatty acid metabolism with positron emission tomography in patients with cardiomyopathy

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