Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

Keyphrases

• Mechanistic Insight 100%
• Dioxygenase 100%
• Antibiotic Biosynthesis 100%
• Quinolone Antibiotics 100%
• Spiro 33%
• Bicyclol 33%
• Epoxides 33%
• Fe(II) 33%
• Reaction Cycle 33%
• Epoxidation 33%
• Sources of Inspiration 33%
• Desaturation 33%
• Natural Products 33%
• Spring-loaded 33%
• Aspergillus Nidulans 33%
• α-ketoglutarate (α-KG) 33%
• Ferryl 33%
• Bicyclic Scaffold 33%
• Quinoline Alkaloids 33%
• Benzodiazepinedione 33%
• Synthetic Chemists 33%
• Chemoenzymatic Cascades 33%

Biochemistry, Genetics and Molecular Biology

• Dioxygenase 100%
• Antibiotic Biosynthesis 100%
• Crystal Structure 33%
• Epoxidation 33%
• Anabolism 33%
• Fatty Acid Desaturation 33%
• Aspergillus nidulans 33%

Chemistry

• Dioxygenase 100%
• Quinoline Derived Antiinfective Agent 100%
• Crystal Structure 33%
• Spiro-Epoxide 33%
• Quinolone 33%
• epoxidation 33%
• Natural Product 33%