Structural investigation of cisplatin-protein interactions: Selective platination of His19 in a cuprozinc superoxide dismutase

Vito Calderone; Angela Casini; Stefano Mangani; Luigi Messori; Pier Luigi Orioli

doi:10.1002/anie.200502599

Structural investigation of cisplatin-protein interactions: Selective platination of His19 in a cuprozinc superoxide dismutase

Vito Calderone, Angela Casini, Stefano Mangani, Luigi Messori, Pier Luigi Orioli

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper-zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands (see picture, Cu orange, Zn dark gray, Pt light gray, Cl green). (Figure Presented)

Original language	English
Pages (from-to)	1267-1269
Number of pages	3
Journal	Angewandte Chemie International Edition in English
Volume	45
Issue number	8
DOIs	https://doi.org/10.1002/anie.200502599
State	Published - 13 Feb 2006
Externally published	Yes

Keywords

Antitumor agents
Cisplatin
Platinum
Superoxide dismutase
X-ray diffraction

Access to Document

10.1002/anie.200502599

Cite this

@article{072b55c2525d4c798830a930829ff02d,

title = "Structural investigation of cisplatin-protein interactions: Selective platination of His19 in a cuprozinc superoxide dismutase",

abstract = "Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-{\AA} resolution. Selective platination of His19 occurs far away from the copper-zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands (see picture, Cu orange, Zn dark gray, Pt light gray, Cl green). (Figure Presented)",

keywords = "Antitumor agents, Cisplatin, Platinum, Superoxide dismutase, X-ray diffraction",

author = "Vito Calderone and Angela Casini and Stefano Mangani and Luigi Messori and Orioli, {Pier Luigi}",

year = "2006",

month = feb,

day = "13",

doi = "10.1002/anie.200502599",

language = "English",

volume = "45",

pages = "1267--1269",

journal = "Angewandte Chemie International Edition in English",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "8",

}

TY - JOUR

T1 - Structural investigation of cisplatin-protein interactions

T2 - Selective platination of His19 in a cuprozinc superoxide dismutase

AU - Calderone, Vito

AU - Casini, Angela

AU - Mangani, Stefano

AU - Messori, Luigi

AU - Orioli, Pier Luigi

PY - 2006/2/13

Y1 - 2006/2/13

N2 - Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper-zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands (see picture, Cu orange, Zn dark gray, Pt light gray, Cl green). (Figure Presented)

AB - Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper-zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands (see picture, Cu orange, Zn dark gray, Pt light gray, Cl green). (Figure Presented)

KW - Antitumor agents

KW - Cisplatin

KW - Platinum

KW - Superoxide dismutase

KW - X-ray diffraction

UR - http://www.scopus.com/inward/record.url?scp=33746214624&partnerID=8YFLogxK

U2 - 10.1002/anie.200502599

DO - 10.1002/anie.200502599

M3 - Article

C2 - 16416478

AN - SCOPUS:33746214624

SN - 1433-7851

VL - 45

SP - 1267

EP - 1269

JO - Angewandte Chemie International Edition in English

JF - Angewandte Chemie International Edition in English

IS - 8

ER -

Structural investigation of cisplatin-protein interactions: Selective platination of His19 in a cuprozinc superoxide dismutase

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this