Structural and functional asymmetry of the neonatal cerebral cortex

Logan Z.J. Williams; Sean P. Fitzgibbon; Jelena Bozek; Anderson M. Winkler; Ralica Dimitrova; Tanya Poppe; Andreas Schuh; Antonios Makropoulos; John Cupitt; Jonathan O’Muircheartaigh; Eugene P. Duff; Lucilio Cordero-Grande; Anthony N. Price; Joseph V. Hajnal; Daniel Rueckert; Stephen M. Smith; A. David Edwards; Emma C. Robinson

doi:10.1038/s41562-023-01542-8

Structural and functional asymmetry of the neonatal cerebral cortex

Logan Z.J. Williams, Sean P. Fitzgibbon, Jelena Bozek, Anderson M. Winkler, Ralica Dimitrova, Tanya Poppe, Andreas Schuh, Antonios Makropoulos, John Cupitt, Jonathan O’Muircheartaigh, Eugene P. Duff, Lucilio Cordero-Grande, Anthony N. Price, Joseph V. Hajnal, Daniel Rueckert, Stephen M. Smith, A. David Edwards, Emma C. Robinson

Informatics 31 - Chair of Artificial Intelligence in Healthcare and Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Features of brain asymmetry have been implicated in a broad range of cognitive processes; however, their origins are still poorly understood. Here we investigated cortical asymmetries in 442 healthy term-born neonates using structural and functional magnetic resonance images from the Developing Human Connectome Project. Our results demonstrate that the neonatal cortex is markedly asymmetric in both structure and function. Cortical asymmetries observed in the term cohort were contextualized in two ways: by comparing them against cortical asymmetries observed in 103 preterm neonates scanned at term-equivalent age, and by comparing structural asymmetries against those observed in 1,110 healthy young adults from the Human Connectome Project. While associations with preterm birth and biological sex were minimal, significant differences exist between birth and adulthood.

Original language	English
Pages (from-to)	942-955
Number of pages	14
Journal	Nature Human Behaviour
Volume	7
Issue number	6
DOIs	https://doi.org/10.1038/s41562-023-01542-8
State	Published - Jun 2023

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Williams, L. Z. J., Fitzgibbon, S. P., Bozek, J., Winkler, A. M., Dimitrova, R., Poppe, T., Schuh, A., Makropoulos, A., Cupitt, J., O’Muircheartaigh, J., Duff, E. P., Cordero-Grande, L., Price, A. N., Hajnal, J. V., Rueckert, D., Smith, S. M., Edwards, A. D., & Robinson, E. C. (2023). Structural and functional asymmetry of the neonatal cerebral cortex. Nature Human Behaviour, 7(6), 942-955. https://doi.org/10.1038/s41562-023-01542-8

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title = "Structural and functional asymmetry of the neonatal cerebral cortex",

abstract = "Features of brain asymmetry have been implicated in a broad range of cognitive processes; however, their origins are still poorly understood. Here we investigated cortical asymmetries in 442 healthy term-born neonates using structural and functional magnetic resonance images from the Developing Human Connectome Project. Our results demonstrate that the neonatal cortex is markedly asymmetric in both structure and function. Cortical asymmetries observed in the term cohort were contextualized in two ways: by comparing them against cortical asymmetries observed in 103 preterm neonates scanned at term-equivalent age, and by comparing structural asymmetries against those observed in 1,110 healthy young adults from the Human Connectome Project. While associations with preterm birth and biological sex were minimal, significant differences exist between birth and adulthood.",

author = "Williams, {Logan Z.J.} and Fitzgibbon, {Sean P.} and Jelena Bozek and Winkler, {Anderson M.} and Ralica Dimitrova and Tanya Poppe and Andreas Schuh and Antonios Makropoulos and John Cupitt and Jonathan O{\textquoteright}Muircheartaigh and Duff, {Eugene P.} and Lucilio Cordero-Grande and Price, {Anthony N.} and Hajnal, {Joseph V.} and Daniel Rueckert and Smith, {Stephen M.} and Edwards, {A. David} and Robinson, {Emma C.}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2023",

month = jun,

doi = "10.1038/s41562-023-01542-8",

language = "English",

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Williams, LZJ, Fitzgibbon, SP, Bozek, J, Winkler, AM, Dimitrova, R, Poppe, T, Schuh, A, Makropoulos, A, Cupitt, J, O’Muircheartaigh, J, Duff, EP, Cordero-Grande, L, Price, AN, Hajnal, JV, Rueckert, D, Smith, SM, Edwards, AD & Robinson, EC 2023, 'Structural and functional asymmetry of the neonatal cerebral cortex', Nature Human Behaviour, vol. 7, no. 6, pp. 942-955. https://doi.org/10.1038/s41562-023-01542-8

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AU - Williams, Logan Z.J.

AU - Fitzgibbon, Sean P.

AU - Bozek, Jelena

AU - Winkler, Anderson M.

AU - Dimitrova, Ralica

AU - Poppe, Tanya

AU - Schuh, Andreas

AU - Makropoulos, Antonios

AU - Cupitt, John

AU - O’Muircheartaigh, Jonathan

AU - Duff, Eugene P.

AU - Cordero-Grande, Lucilio

AU - Price, Anthony N.

AU - Hajnal, Joseph V.

AU - Rueckert, Daniel

AU - Smith, Stephen M.

AU - Edwards, A. David

AU - Robinson, Emma C.

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AB - Features of brain asymmetry have been implicated in a broad range of cognitive processes; however, their origins are still poorly understood. Here we investigated cortical asymmetries in 442 healthy term-born neonates using structural and functional magnetic resonance images from the Developing Human Connectome Project. Our results demonstrate that the neonatal cortex is markedly asymmetric in both structure and function. Cortical asymmetries observed in the term cohort were contextualized in two ways: by comparing them against cortical asymmetries observed in 103 preterm neonates scanned at term-equivalent age, and by comparing structural asymmetries against those observed in 1,110 healthy young adults from the Human Connectome Project. While associations with preterm birth and biological sex were minimal, significant differences exist between birth and adulthood.

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Structural and functional asymmetry of the neonatal cerebral cortex

Abstract

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