Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

Dao Le, Friederike Wagner, Masanari Takamiya, I. Lun Hsiao, Gabriela Gil Alvaradejo, Uwe Strähle, Carsten Weiss, Guillaume Delaittre

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

Original languageEnglish
Pages (from-to)3741-3744
Number of pages4
JournalChemical Communications
Volume55
Issue number26
DOIs
StatePublished - 2019
Externally publishedYes

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