Stoffwechsel-Untersuchungen und Lokalisation von Wirkstoffen an kryopraparierten Tumorzellen mit analytischer Transmissionselektronenmikroskopie (TEM-EELS)

B. Wolf; M. Kraus; A. Schwinde; P. Scheipers

Stoffwechsel-Untersuchungen und Lokalisation von Wirkstoffen an kryopraparierten Tumorzellen mit analytischer Transmissionselektronenmikroskopie (TEM-EELS)

Translated title of the contribution: TEM-EELS on cryoprepared samples: Operation in drug targeting and metabolic investigations on tumor cells

B. Wolf
, M. Kraus
, A. Schwinde
, P. Scheipers

University of Freiburg

Research output: Contribution to journal › Article › peer-review

Abstract

With analytical electron microscopy, it is possible to localize drugs and xenobiotics in situ under optical control or to quantify their uptake and distribution in target cells without considerable desintegration of the cell or tissue sample. In the present study, we applied analytical electron energy loss spectroscopy (EELS) in transmission electron microscopy in order to investigate cellular uptake and distribution of cisplatin and cyclophosphamide, as well as metabolic changes induced by extracellular calcium.

Translated title of the contribution	TEM-EELS on cryoprepared samples: Operation in drug targeting and metabolic investigations on tumor cells
Original language	German
Pages (from-to)	67-77
Number of pages	11
Journal	Zeitschrift fur Onkologie
Volume	29
Issue number	3
State	Published - 1997
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Stoffwechsel-Untersuchungen und Lokalisation von Wirkstoffen an kryopraparierten Tumorzellen mit analytischer Transmissionselektronenmikroskopie (TEM-EELS)",

abstract = "With analytical electron microscopy, it is possible to localize drugs and xenobiotics in situ under optical control or to quantify their uptake and distribution in target cells without considerable desintegration of the cell or tissue sample. In the present study, we applied analytical electron energy loss spectroscopy (EELS) in transmission electron microscopy in order to investigate cellular uptake and distribution of cisplatin and cyclophosphamide, as well as metabolic changes induced by extracellular calcium.",

author = "B. Wolf and M. Kraus and A. Schwinde and P. Scheipers",

year = "1997",

language = "Deutsch",

volume = "29",

pages = "67--77",

journal = "Zeitschrift fur Onkologie",

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T1 - Stoffwechsel-Untersuchungen und Lokalisation von Wirkstoffen an kryopraparierten Tumorzellen mit analytischer Transmissionselektronenmikroskopie (TEM-EELS)

AU - Wolf, B.

AU - Kraus, M.

AU - Schwinde, A.

AU - Scheipers, P.

PY - 1997

Y1 - 1997

N2 - With analytical electron microscopy, it is possible to localize drugs and xenobiotics in situ under optical control or to quantify their uptake and distribution in target cells without considerable desintegration of the cell or tissue sample. In the present study, we applied analytical electron energy loss spectroscopy (EELS) in transmission electron microscopy in order to investigate cellular uptake and distribution of cisplatin and cyclophosphamide, as well as metabolic changes induced by extracellular calcium.

AB - With analytical electron microscopy, it is possible to localize drugs and xenobiotics in situ under optical control or to quantify their uptake and distribution in target cells without considerable desintegration of the cell or tissue sample. In the present study, we applied analytical electron energy loss spectroscopy (EELS) in transmission electron microscopy in order to investigate cellular uptake and distribution of cisplatin and cyclophosphamide, as well as metabolic changes induced by extracellular calcium.

UR - https://www.scopus.com/pages/publications/0030867615

M3 - Artikel

AN - SCOPUS:0030867615

SN - 1432-2919

VL - 29

SP - 67

EP - 77

JO - Zeitschrift fur Onkologie

JF - Zeitschrift fur Onkologie

IS - 3

ER -

Stoffwechsel-Untersuchungen und Lokalisation von Wirkstoffen an kryopraparierten Tumorzellen mit analytischer Transmissionselektronenmikroskopie (TEM-EELS)

Abstract

UN SDGs

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