Stoffwechsel-Untersuchungen und Lokalisation von Wirkstoffen an kryopraparierten Tumorzellen mit analytischer Transmissionselektronenmikroskopie (TEM-EELS)

Translated title of the contribution: TEM-EELS on cryoprepared samples: Operation in drug targeting and metabolic investigations on tumor cells

B. Wolf, M. Kraus, A. Schwinde, P. Scheipers

Research output: Contribution to journalArticlepeer-review

Abstract

With analytical electron microscopy, it is possible to localize drugs and xenobiotics in situ under optical control or to quantify their uptake and distribution in target cells without considerable desintegration of the cell or tissue sample. In the present study, we applied analytical electron energy loss spectroscopy (EELS) in transmission electron microscopy in order to investigate cellular uptake and distribution of cisplatin and cyclophosphamide, as well as metabolic changes induced by extracellular calcium.

Translated title of the contributionTEM-EELS on cryoprepared samples: Operation in drug targeting and metabolic investigations on tumor cells
Original languageGerman
Pages (from-to)67-77
Number of pages11
JournalZeitschrift fur Onkologie
Volume29
Issue number3
StatePublished - 1997
Externally publishedYes

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