Stellenwert der Strahlentherapie bei sezernierenden und nichtsezernierenden Hypophysenadenomen

Translated title of the contribution: Importance of radiotherapy for treatment of secreting and non-secreting pituitary adenomas

Christoph Straube, Stephanie E. Combs

Research output: Contribution to journalReview articlepeer-review


Background: This manuscript summarizes the treatment options available in modern radiation oncology for the treatment of secreting and non-secreting pituitary adenomas. Modern high-precision treatment options enable a steep reduction in dosing to healthy tissue and therefore provide excellent local control with low rates of side effects. Objective: Interdisciplinary treatment paradigms can be derived from the available data. Material and methods: This article summarizes the most recent literature on high-precision radiotherapy for the treatment of pituitary adenomas. Furthermore, techniques are described that can be performed as radiosurgery (in one single fraction) or as fractionated regimens for benign tumors. Results: Local control of pituitary adenomas lies between 80–100% depending on the underlying histology, size and location of the lesion. Small volumes can be safely treated with radiosurgery, while fractionated regimens have an improved therapeutic window also in larger lesions. Radiotherapy is an effective option for persisting hormone secretion; however, normalization of hormone secretion is a continuous process. Conclusion: Modern radiation oncology provides excellent treatment alternatives for benign lesions, such as pituitary adenomas with a favorable risk-benefit profile and should be considered in the interdisciplinary decision making process.

Translated title of the contributionImportance of radiotherapy for treatment of secreting and non-secreting pituitary adenomas
Original languageGerman
Pages (from-to)143-150
Number of pages8
Issue number2
StatePublished - 1 Feb 2018
Externally publishedYes


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