@inproceedings{cfd4b1ee1bd8475eafcad8389afddaea,
title = "Statistical iterative reconstruction for multi-contrast x-ray micro-tomography",
abstract = "Scanning times have always been an important issue in x-ray micro-tomography. To reach high-quality reconstructions the exposure times for each projection can be very long due to small detector pixel sizes and limited flux of x-ray sources. In addition, the required number of projections is a factor which limits a reduction of exposure beyond a certain level. This applies particularly to grating-based phase-contrast computed tomography (PCCT), as several images per projection have to be acquired in order to obtain absorption, phase and dark-field information. In this work we qualitatively compare statistical iterative reconstruction (SIR) and filtered back-projection (FBP) reconstruction from undersampled projection data based on a formalin-fixated mouse sample measured in a grating-based phase-contrast small-animal scanner. The results from our assessment illustrate that SIR offers not only significantly higher image quality, but also enables high-resolution imaging from severely undersampled data in comparison to the FBP algorithm. Therefore, the application of advanced iterative reconstruction methods in micro-tomography entails major advantages over state-of-the-art FBP reconstruction while offering the opportunity to shorten scan durations via a reduction of exposure time per projection and number of angular views.",
keywords = "Computed tomography, Grating-based phase-contrast CT, Micro-CT, Noise reduction, Statistical iterative reconstruction, Undersampling",
author = "S. Allner and A. Velroyen and A. Fehringer and F. Pfeiffer and No{\"e}l, {P. B.}",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Medical Imaging 2015: Physics of Medical Imaging ; Conference date: 22-02-2015 Through 25-02-2015",
year = "2015",
doi = "10.1117/12.2082619",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Christoph Hoeschen and Despina Kontos and Christoph Hoeschen",
booktitle = "Medical Imaging 2015",
}